Switchable Synthesis of Z-Homoallylic Boronates and E-Allylic Boronates by Enantioselective Copper-Catalyzed 1,6-Boration

Yunfei Luo, Steven M. Wales, Stamatis E. Korkis, Iain D. Roy, William Lewis, Hon Wai Lam*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Abstract

The enantioselective Cu-catalyzed 1,6-boration of (E,E)-α,β,γ,δ-unsaturated ketones is described, which gives homoallylic boronates with high enantiomeric purity and unexpectedly high Z-selectivity. By changing the solvent, the outcome can be altered to give E-allylic boronates.

Original languageEnglish
Pages (from-to)8315-8319
Number of pages5
JournalChemistry - A European Journal
Volume24
Issue number33
Early online date17 Apr 2018
DOIs
Publication statusPublished - 12 Jun 2018

Keywords

  • 1,6-addition
  • asymmetric catalysis
  • boron
  • copper
  • enantioselectivity

Fingerprint Dive into the research topics of 'Switchable Synthesis of Z-Homoallylic Boronates and E-Allylic Boronates by Enantioselective Copper-Catalyzed 1,6-Boration'. Together they form a unique fingerprint.

Cite this