Projects per year
Abstract
AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate most fast excitatory neurotransmission. The component subunits determine the functional properties of AMPARs, and the prevailing view is that the subunit composition also determines AMPAR trafficking, which is dynamically regulated during development, synaptic plasticity and in response to neuronal stress in disease. Recently, the subunit dependence of AMPAR trafficking has been questioned, leading to a reappraisal of this field. In this Review, we discuss what is known, uncertain, conjectured and unknown about the roles of the individual subunits, and how they affect AMPAR assembly, trafficking and function under both normal and pathological conditions.
Original language | English |
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Pages (from-to) | 337–350 |
Number of pages | 14 |
Journal | Nature Reviews Neuroscience |
Volume | 17 |
Issue number | 6 |
Early online date | 15 Apr 2016 |
DOIs | |
Publication status | Published - Jun 2016 |
Keywords
- Long-term potentiation
- Neurotransmitters
- Synaptic plasticity
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Projects
- 3 Finished
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Targets and mechanisms of SUMOylation-mediated cardioprotection during ischemia and reperfusion injury
1/04/15 → 3/10/19
Project: Research
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Roles of protein SUMOylation in AMPA receptor trafficking, synaptic dysfunction and cognitive impairment in dementia
1/03/14 → 30/06/18
Project: Research
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