Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

TVP Bliss, Graham Collingridge, BK Kaang, M Zhou

Research output: Contribution to journalReview article (Academic Journal)peer-review

191 Citations (Scopus)

Abstract

The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this Review, we discuss increasing evidence from rodent studies that ACC activation contributes to chronic pain states and describe several forms of synaptic plasticity that may underlie this effect. In particular, one form of long-term potentiation (LTP) in the ACC, which is triggered by the activation of NMDA receptors and expressed by an increase in AMPA-receptor function, sustains the affective component of the pain state. Another form of LTP in the ACC, which is triggered by the activation of kainate receptors and expressed by an increase in glutamate release, may contribute to pain-related anxiety.
Original languageEnglish
Pages (from-to)485
Number of pages496
JournalNature Reviews Neuroscience
Volume17
Issue number8
Early online date16 Jun 2016
DOIs
Publication statusPublished - 16 Jun 2016

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