Synaptic plasticity of kainate receptors

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)

Abstract

Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors. The third subtype of ionotropic glutamate receptor, kainate receptors, has not been studied to the same extent, but recent evidence shows that these receptors also exhibit synaptic plasticity in response to activity. There is also a growing body of data on the mechanisms underlying kainate receptor trafficking and the proteins they interact with. This review summarizes the current state of knowledge on this topic, focusing on the evidence for the removal or insertion of functional kainate receptors in response to synaptic activity and the cellular mechanisms that underlie this regulation of neuronal kainate receptor function.
Translated title of the contributionSynaptic plasticity of kainate receptors
Original languageEnglish
Pages (from-to)949 - 951
Number of pages3
JournalBiochemical Society Transactions
Volume34(5)
DOIs
Publication statusPublished - Nov 2006

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