Syndecan and integrin interactomes: large complexes in small spaces

James Roper, Roz C Williamson, Mark D Bass

Research output: Contribution to journalArticle (Academic Journal)peer-review

50 Citations (Scopus)


The syndecan family of transmembrane proteoglycans cooperate with integrins to
regulate both early and late events in adhesion formation. The heparan sulphate
chains substituted on to the syndecan ectodomains are capable of engaging ligands over great distance, while the protein core spans the plasma membrane and initiates cytoplasmic signals through a short cytoplasmic tail. These properties create a spatial paradox. The volume of the heparan sulphate chains greatly exceeds that of the integrins with which it cooperates, while the short cytodomain must bind to multiple cytoplasmic factors, despite being long enough to bind only one or two. In this review we consider the structural rearrangements that a cell undertakes to overcome spatial restrictions and compare the interactomes of syndecans and integrins to gain insight into the composition of adhesions and how they are regulated over time.
Original languageEnglish
Pages (from-to)583-590
JournalCurrent Opinion in Structural Biology
Early online date26 Jul 2012
Publication statusPublished - 16 Oct 2012

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