Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies

Aliya Sarmanova, Michelle Hall, J Moses, Michael University of Nottingham, W Zhang

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

OBJECTIVES: To examine the prevalence of synovial effusion, synovial hypertrophy and positive Doppler signal (DS) detected by ultrasound (US) in people with knee osteoarthritis (OA) and/or knee pain compared to that in the general population.

METHOD: A systematic literature search was undertaken in Medline, EMBASE, Allied and Complementary Medicine, PubMed Web of Science, and SCOPUS databases in May 2015. Frequencies of US abnormalities in people with knee OA/pain, in the general population or asymptomatic controls were pooled using the random effects model. Publication bias and heterogeneity between studies were examined.

RESULTS: Twenty four studies in people with knee pain/OA and five studies of the general population or asymptomatic controls met the inclusion criteria. The pooled prevalence of US effusion, synovial hypertrophy and positive DS in people with knee OA/pain were 51.5% (95% CI 40.2 to 62.8), 41.5% (26.3-57.5) and 32.7% (8.34-63.24), respectively, which were higher than those in the general population or asymptomatic controls (19.9% (95%CI 7.8-35.3%), 14.5% (0-58.81), and 15.8 (3.08-35.36), respectively). People with knee OA (ACR criteria or radiographic OA) had greater prevalence of US abnormalities than people with knee pain (P = 0.037, P = 0.010 and P = 0.009, respectively).

CONCLUSIONS: US detected effusion, synovial hypertrophy and DS are more common in people with knee OA/pain, compared to the general population. These abnormalities relate more to presence of OA structural changes than to pain.

Original languageEnglish
Pages (from-to)1376-1383
Number of pages8
JournalOsteoarthritis and Cartilage
Volume24
Issue number8
Early online date20 Mar 2016
DOIs
Publication statusPublished - Aug 2016

Bibliographical note

Special issue: Abstracts from the 2016 OARSI World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis

Keywords

  • Humans
  • Knee Joint
  • Osteoarthritis, Knee
  • Severity of Illness Index
  • Synovitis
  • Ultrasonography

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