Synthesis and Pharmacological Characterization of N3-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLUK5 Kainate Receptor Antagonists

NP Dolman; JC-A More; A Alt; JL Knauss; OT Pentikäinen; CR Glasser; D Bleakman; ML Mayer; GL Collingridge; DE Jane

doi:10.1021/jm061041u

Synthesis and Pharmacological Characterization of N³-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLU_K5 Kainate Receptor Antagonists

NP Dolman, JC-A More, A Alt, JL Knauss, OT Pentikäinen, CR Glasser, D Bleakman, ML Mayer, GL Collingridge, DE Jane

Research output: Contribution to journal › Article (Academic Journal) › peer-review

68 Citations (Scopus)

Translated title of the contribution	Synthesis and Pharmacological Characterization of N³-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLU_K5 Kainate Receptor Antagonists
Original language	English
Pages (from-to)	1558 - 1570
Number of pages	13
Journal	Journal of Medicinal Chemistry
Volume	50 (7)
DOIs	https://doi.org/10.1021/jm061041u
Publication status	Published - Apr 2007

Bibliographical note

Publisher: American Chemical Society

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10.1021/jm061041u

http://pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/2007/50/i07/abs/jm061041u.html

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ELUCIDATION OF THE ROLE OF KAINATE RECEPTORS IN HIPPOCAMPAL SYNAPTIC MECHANISMS USING NOVEL PHARMACOLOGICAL TOOLS
Jane, D. E. (Principal Investigator)
1/10/04 → 1/01/08
Project: Research

Cite this

Dolman, NP., More, JC.-A., Alt, A., Knauss, JL., Pentikäinen, OT., Glasser, CR., Bleakman, D., Mayer, ML., Collingridge, GL., & Jane, DE. (2007). Synthesis and Pharmacological Characterization of N³-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLU_K5 Kainate Receptor Antagonists. Journal of Medicinal Chemistry, 50 (7), 1558 - 1570. https://doi.org/10.1021/jm061041u

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title = "Synthesis and Pharmacological Characterization of N3-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLUK5 Kainate Receptor Antagonists",

author = "NP Dolman and JC-A More and A Alt and JL Knauss and OT Pentik{\"a}inen and CR Glasser and D Bleakman and ML Mayer and GL Collingridge and DE Jane",

note = "Publisher: American Chemical Society",

year = "2007",

month = apr,

doi = "10.1021/jm061041u",

language = "English",

volume = "50 (7)",

pages = "1558 -- 1570",

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Dolman, NP, More, JC-A, Alt, A, Knauss, JL, Pentikäinen, OT, Glasser, CR, Bleakman, D, Mayer, ML, Collingridge, GL & Jane, DE 2007, 'Synthesis and Pharmacological Characterization of N³-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLU_K5 Kainate Receptor Antagonists', Journal of Medicinal Chemistry, vol. 50 (7), pp. 1558 - 1570. https://doi.org/10.1021/jm061041u

Synthesis and Pharmacological Characterization of N³-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLU_K5 Kainate Receptor Antagonists. / Dolman, NP; More, JC-A; Alt, A et al.
In: Journal of Medicinal Chemistry, Vol. 50 (7), 04.2007, p. 1558 - 1570.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Synthesis and Pharmacological Characterization of N3-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLUK5 Kainate Receptor Antagonists

AU - Dolman, NP

AU - More, JC-A

AU - Alt, A

AU - Knauss, JL

AU - Pentikäinen, OT

AU - Glasser, CR

AU - Bleakman, D

AU - Mayer, ML

AU - Collingridge, GL

AU - Jane, DE

N1 - Publisher: American Chemical Society

PY - 2007/4

Y1 - 2007/4

U2 - 10.1021/jm061041u

DO - 10.1021/jm061041u

M3 - Article (Academic Journal)

C2 - 17348638

SN - 1520-4804

VL - 50 (7)

SP - 1558

EP - 1570

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

ER -

Dolman NP, More JCA, Alt A, Knauss JL, Pentikäinen OT, Glasser CR et al. Synthesis and Pharmacological Characterization of N³-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLU_K5 Kainate Receptor Antagonists. Journal of Medicinal Chemistry. 2007 Apr;50 (7):1558 - 1570. doi: 10.1021/jm061041u