TY - JOUR
T1 - Synthesis, Antimicrobial, and Brine Shrimps Lethality Assays of 3,3-Diaryl-4-(1-methyl-1H-indol-3-yl)azetidin-2-ones
AU - Singh, Girija S.
AU - Al‐kahraman, Yasser M. S. A.
AU - Mpadi, Disah
AU - Yasinzai, Masoom
PY - 2014/5/21
Y1 - 2014/5/21
N2 - The paper describes the synthesis, characterization data, and biological activity (antibacterial, antifungal, and brine shrimps lethality) of new azetidin‐2‐ones. The compounds have been synthesized by the reaction of diarylketenes, generated in situ from thermal decomposition of the 2‐diazo‐1,2‐diarylethanones, with N‐(1‐methyl‐1H‐indol‐3‐yl)methyleneamines. The compounds have been characterized by elemental analysis and spectral (IR, 1H and 13C NMR, and MS) data. The paper also reports the results of antibacterial, antifungal, and brine shrimps lethality assays of these compounds. Some of the compounds exhibited significant biological activity.
AB - The paper describes the synthesis, characterization data, and biological activity (antibacterial, antifungal, and brine shrimps lethality) of new azetidin‐2‐ones. The compounds have been synthesized by the reaction of diarylketenes, generated in situ from thermal decomposition of the 2‐diazo‐1,2‐diarylethanones, with N‐(1‐methyl‐1H‐indol‐3‐yl)methyleneamines. The compounds have been characterized by elemental analysis and spectral (IR, 1H and 13C NMR, and MS) data. The paper also reports the results of antibacterial, antifungal, and brine shrimps lethality assays of these compounds. Some of the compounds exhibited significant biological activity.
M3 - Article (Academic Journal)
SN - 0022-152X
VL - 52
SP - 614
EP - 619
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 2
ER -