Synthesis, characterization and biological studies of a novel Cu(II) Schiff base complex

Thangavel Thirunavukkarasu; Hazel A. Sparkes; Karuppannan Natarajan; V. G. Gnanasoundari

doi:10.1016/j.ica.2018.01.006

Synthesis, characterization and biological studies of a novel Cu(II) Schiff base complex

Thangavel Thirunavukkarasu, Hazel A. Sparkes, Karuppannan Natarajan^*, V. G. Gnanasoundari

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

A Cu(II) complex was obtained from the reaction of 4-(diethylamino)-3-quinolin-3-ylimino-methyl-2-phenol with [CuCl2(PPh3)2]. The ligand coordinated to the metal ion in a monobasic bidentate fashion. The molecular structure of the complex has been confirmed by single crystal X-ray diffraction. Both the ligand and complex were characterized by various spectroscopic techniques. Using the UV-visible and fluorescence spectroscopic studies, the binding interactions of the compounds with CT-DNA and bovine serum albumin protein were evaluated. The results indicated that the compounds are efficient DNA/protein binders. The cytotoxicity of the ligand and complex against A549 (lung cancer) and MCF7 (breast cancer) cell lines was also investigated in vitro conditions using the MTT assay method which showed significant anticancer activity.

Original language	English
Pages (from-to)	255-262
Number of pages	8
Journal	Inorganica Chimica Acta
Volume	473
Early online date	9 Jan 2018
DOIs	https://doi.org/10.1016/j.ica.2018.01.006
Publication status	Published - 24 Mar 2018

Keywords

Schiff base ligand
Copper(II) complex
DNA/protein binding
Cytotoxicity

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title = "Synthesis, characterization and biological studies of a novel Cu(II) Schiff base complex",

abstract = "A Cu(II) complex was obtained from the reaction of 4-(diethylamino)-3-quinolin-3-ylimino-methyl-2-phenol with [CuCl2(PPh3)2]. The ligand coordinated to the metal ion in a monobasic bidentate fashion. The molecular structure of the complex has been confirmed by single crystal X-ray diffraction. Both the ligand and complex were characterized by various spectroscopic techniques. Using the UV-visible and fluorescence spectroscopic studies, the binding interactions of the compounds with CT-DNA and bovine serum albumin protein were evaluated. The results indicated that the compounds are efficient DNA/protein binders. The cytotoxicity of the ligand and complex against A549 (lung cancer) and MCF7 (breast cancer) cell lines was also investigated in vitro conditions using the MTT assay method which showed significant anticancer activity. ",

keywords = "Schiff base ligand , Copper(II) complex, DNA/protein binding, Cytotoxicity",

author = "Thangavel Thirunavukkarasu and Sparkes, {Hazel A.} and Karuppannan Natarajan and Gnanasoundari, {V. G.}",

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T1 - Synthesis, characterization and biological studies of a novel Cu(II) Schiff base complex

AU - Thirunavukkarasu, Thangavel

AU - Sparkes, Hazel A.

AU - Natarajan, Karuppannan

AU - Gnanasoundari, V. G.

PY - 2018/3/24

Y1 - 2018/3/24

N2 - A Cu(II) complex was obtained from the reaction of 4-(diethylamino)-3-quinolin-3-ylimino-methyl-2-phenol with [CuCl2(PPh3)2]. The ligand coordinated to the metal ion in a monobasic bidentate fashion. The molecular structure of the complex has been confirmed by single crystal X-ray diffraction. Both the ligand and complex were characterized by various spectroscopic techniques. Using the UV-visible and fluorescence spectroscopic studies, the binding interactions of the compounds with CT-DNA and bovine serum albumin protein were evaluated. The results indicated that the compounds are efficient DNA/protein binders. The cytotoxicity of the ligand and complex against A549 (lung cancer) and MCF7 (breast cancer) cell lines was also investigated in vitro conditions using the MTT assay method which showed significant anticancer activity.

AB - A Cu(II) complex was obtained from the reaction of 4-(diethylamino)-3-quinolin-3-ylimino-methyl-2-phenol with [CuCl2(PPh3)2]. The ligand coordinated to the metal ion in a monobasic bidentate fashion. The molecular structure of the complex has been confirmed by single crystal X-ray diffraction. Both the ligand and complex were characterized by various spectroscopic techniques. Using the UV-visible and fluorescence spectroscopic studies, the binding interactions of the compounds with CT-DNA and bovine serum albumin protein were evaluated. The results indicated that the compounds are efficient DNA/protein binders. The cytotoxicity of the ligand and complex against A549 (lung cancer) and MCF7 (breast cancer) cell lines was also investigated in vitro conditions using the MTT assay method which showed significant anticancer activity.

KW - Schiff base ligand

KW - Copper(II) complex

KW - DNA/protein binding

KW - Cytotoxicity

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DO - 10.1016/j.ica.2018.01.006

M3 - Article (Academic Journal)

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VL - 473

SP - 255

EP - 262

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

SN - 0020-1693

ER -

Synthesis, characterization and biological studies of a novel Cu(II) Schiff base complex

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