Synthesis of 2,2c-6-trisubstituted and 2,2c-,6,6--tetrasubstituted diaryl sulfides and diaryl sulfones by copper-promoted coupling and/or ortholithiation

Jonathan Clayden*, James Senior

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)

Abstract

Stoichiometric copper(I) iodide, in the presence of potassium carbonate and ethylene glycol, promotes the coupling of even highly sterically encumbered 2,6-disubstituted thiophenols and aryl iodides to form hindered diarylsulfides. Hindered diarylsulfones may be made in a complementary fashion by ortholithiation of the sulfone oxidation products of less hindered diarylsulfides.

Original languageEnglish
Pages (from-to)2769-2772
Number of pages4
JournalSYNLETT
Issue number17
DOIs
Publication statusPublished - 24 Sep 2009

Keywords

  • Copper
  • Coupling
  • Lithiation
  • Sulfide
  • Sulfone
  • Ullmann

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