Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence

Timothy J. Donohoe*, John F. Bower, David B. Baker, José A. Basutto, Louis K M Chan, Peter Gallagher

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

29 Citations (Scopus)

Abstract

Heck reactions were performed on α,β-unsaturated-δ- sulfonamido intermediates, derived from cross metathesis, to allow the instalment of substituents at the β position. Subsequent one-pot cyclisation/elimination provides an operationally simple, catalytic and convergent synthesis of 2,4,6-trisubstituted pyridines.

Original languageEnglish
Pages (from-to)10611-10613
Number of pages3
JournalChemical Communications
Volume47
Issue number38
DOIs
Publication statusPublished - 14 Oct 2011

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