Synthesis of enantiomerically enriched isotopically-labelled anilines by (-)-sparteine directed lithiation

Jonathan Clayden*, Loïc Lemiègre, Mark Pickworth

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)

Abstract

Anilines bearing benzyl or isopropyl groups isotopically labelled (with 2H or 13C) in one of a pair of enantiotopic protons or methyl groups can be made using (-)-sparteine-directed lithiation with an electrophilic quench, followed by deprotection.

Original languageEnglish
Pages (from-to)2218-2221
Number of pages4
JournalTetrahedron: Asymmetry
Volume19
Issue number18
DOIs
Publication statusPublished - 22 Sep 2008

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