Projects per year
Abstract
The Zweifel reaction is a powerful method for the synthesis of alkenes, serving as a transition-metal-free alternative to the Suzuki-Miyaura reaction. To date, the scope of the Zweifel coupling has been rather narrow and has focused mainly on the coupling of vinyllithium reagents to synthesize simple aryl- and alkyl-substituted olefins. Herein, the development of a general transition-metal-free coupling process enabling the coupling of Grignard reagents or organolithiums is described. This method enables the enantiospecific synthesis of a wide variety of functionalized acyclic and cyclic olefin products.
Original language | English |
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Pages (from-to) | 2762-2765 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 19 |
Issue number | 10 |
Early online date | 28 Apr 2017 |
DOIs | |
Publication status | Published - 19 May 2017 |
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Dive into the research topics of 'Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling'. Together they form a unique fingerprint.Projects
- 2 Finished
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
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Changing the Synthesis Landscape with Boron at the Helm: from Chiral Organometallics to Assembly Line Synthesis
Aggarwal, V. K. (Principal Investigator)
14/05/12 → 13/01/18
Project: Research