Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling

Roly J. Armstrong, Worawat Niwetmarin, Varinder K. Aggarwal*

*Corresponding author for this work

Research output: Contribution to journalLetter (Academic Journal)peer-review

62 Citations (Scopus)
432 Downloads (Pure)


The Zweifel reaction is a powerful method for the synthesis of alkenes, serving as a transition-metal-free alternative to the Suzuki-Miyaura reaction. To date, the scope of the Zweifel coupling has been rather narrow and has focused mainly on the coupling of vinyllithium reagents to synthesize simple aryl- and alkyl-substituted olefins. Herein, the development of a general transition-metal-free coupling process enabling the coupling of Grignard reagents or organolithiums is described. This method enables the enantiospecific synthesis of a wide variety of functionalized acyclic and cyclic olefin products.

Original languageEnglish
Pages (from-to)2762-2765
Number of pages4
JournalOrganic Letters
Issue number10
Early online date28 Apr 2017
Publication statusPublished - 19 May 2017


Dive into the research topics of 'Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling'. Together they form a unique fingerprint.

Cite this