Synthesis of Hetero-Polymer Functionalized Nanocarriers by Combining Surface-Initiated ATRP and RAFT Polymerization

Xin Huang; Nicole Hauptmann; Dietmar Appelhans; Petr Formanek; Simon Frank; Stefan Kaskel; Achim Temme; Brigitte Voit

doi:10.1002/smll.201201397

Synthesis of Hetero-Polymer Functionalized Nanocarriers by Combining Surface-Initiated ATRP and RAFT Polymerization

Xin Huang, Nicole Hauptmann, Dietmar Appelhans, Petr Formanek, Simon Frank, Stefan Kaskel, Achim Temme, Brigitte Voit

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

45 Citations (Scopus)

Abstract

Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.

Original language	English
Pages (from-to)	3579-3583
Journal	Small
Volume	8
Issue number	23
DOIs	https://doi.org/10.1002/smll.201201397
Publication status	Published - 7 Dec 2012

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title = "Synthesis of Hetero-Polymer Functionalized Nanocarriers by Combining Surface-Initiated ATRP and RAFT Polymerization",

abstract = "Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.",

author = "Xin Huang and Nicole Hauptmann and Dietmar Appelhans and Petr Formanek and Simon Frank and Stefan Kaskel and Achim Temme and Brigitte Voit",

note = "Copyright {\textcopyright} 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

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T1 - Synthesis of Hetero-Polymer Functionalized Nanocarriers by Combining Surface-Initiated ATRP and RAFT Polymerization

AU - Huang, Xin

AU - Hauptmann, Nicole

AU - Appelhans, Dietmar

AU - Formanek, Petr

AU - Frank, Simon

AU - Kaskel, Stefan

AU - Temme, Achim

AU - Voit, Brigitte

PY - 2012/12/7

Y1 - 2012/12/7

N2 - Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.

AB - Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.

U2 - 10.1002/smll.201201397

DO - 10.1002/smll.201201397

M3 - Article (Academic Journal)

C2 - 22911545

SN - 1613-6810

VL - 8

SP - 3579

EP - 3583

JO - Small

JF - Small

IS - 23

ER -

Synthesis of Hetero-Polymer Functionalized Nanocarriers by Combining Surface-Initiated ATRP and RAFT Polymerization

Abstract

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