Synthesis of Highly Efficient Multivalent Disaccharide/[60]Fullerene Nanoballs for Emergent Viruses

Javier Ramos-Soriano, José J. Reina, Beatriz M. Illescas*, Noelia De La Cruz, Laura Rodríguez-Pérez, Fátima Lasala, Javier Rojo, Rafael Delgado, Nazario Martín

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Abstract

After the last epidemic of the Zika virus (ZIKV) in Brazil that peaked in 2016, growing evidence has been demonstrated of the link between this teratogenic flavivirus and microcephaly cases. However, no vaccine or antiviral drug has been approved yet. ZIKV and Dengue viruses (DENV) entry to the host cell takes place through several receptors, including dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), so that the blockade of this receptor through multivalent glycoconjugates supposes a promising biological target to inhibit the infection process. In order to get enhanced multivalency in biocompatible systems, tridecafullerenes appended with up to 360 1,2-mannobiosides have been synthesized using a strain-promoted cycloaddition of azides to alkynes (SPAAC) strategy. These systems have been tested against ZIKV and DENV infection, showing an outstanding activity in the picomolar range.

Original languageEnglish
Pages (from-to)15403-15412
Number of pages10
JournalJournal of the American Chemical Society
Volume141
Issue number38
DOIs
Publication statusPublished - 25 Sep 2019

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    Ramos-Soriano, J., Reina, J. J., Illescas, B. M., De La Cruz, N., Rodríguez-Pérez, L., Lasala, F., Rojo, J., Delgado, R., & Martín, N. (2019). Synthesis of Highly Efficient Multivalent Disaccharide/[60]Fullerene Nanoballs for Emergent Viruses. Journal of the American Chemical Society, 141(38), 15403-15412. https://doi.org/10.1021/jacs.9b08003