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Abstract
The chemical synthesis of a series of mucin-type oligosaccharide fragments 1-7 containing an α-linked aminopropyl spacer ready for glycoarray attachment is reported. A highly convergent and stereoselective strategy that employs two different orthogonal protected galactosamine building blocks was used to access all of the targets. A tandem deprotection sequence, that did not require chromatography-based purification between steps, was employed to globally unmask all protecting groups and all final targets were isolated in good to excellent yields.
Original language | English |
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Pages (from-to) | 1867-72 |
Number of pages | 6 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 9 |
DOIs | |
Publication status | Published - 2013 |
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Projects
- 2 Finished