Synthesis of mucin-type O-glycan probes as aminopropyl glycosides

David Benito-Alifonso, Rachel A Jones, Anh-Tuan Tran, Hannah Woodward, Nichola Smith, M Carmen Galan

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)

Abstract

The chemical synthesis of a series of mucin-type oligosaccharide fragments 1-7 containing an α-linked aminopropyl spacer ready for glycoarray attachment is reported. A highly convergent and stereoselective strategy that employs two different orthogonal protected galactosamine building blocks was used to access all of the targets. A tandem deprotection sequence, that did not require chromatography-based purification between steps, was employed to globally unmask all protecting groups and all final targets were isolated in good to excellent yields.
Original languageEnglish
Pages (from-to)1867-72
Number of pages6
JournalBeilstein Journal of Organic Chemistry
Volume9
DOIs
Publication statusPublished - 2013

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