Skip to content

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

Research output: Contribution to journalArticle

Original languageEnglish
Article numbereaaw2853
Number of pages9
JournalScience Advances
Issue number9
DateAccepted/In press - 21 Aug 2019
DatePublished (current) - 25 Sep 2019


Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of multiple immunogenic epitopes from pathogens. We used cryo–electron microscopy at near-atomic resolution and implemented novel, cost-effective, high-performance cloud computing to reveal architectural features in unprecedented detail. We analyzed ADDomer interaction with components of the immune system and developed a promising first-in-kind ADDomer-based vaccine candidate to combat emerging Chikungunya infectious disease, exemplifying the potential of our approach.

    Structured keywords

  • Bristol BioDesign Institute
  • BrisSynBio

    Research areas

  • SYNTHETIC BIOLOGY, minimal biology, Biodesign, Vaccine, advanced computing

Download statistics

No data available



  • Full-text PDF (final published version)

    Rights statement: This is the final published version of the article (version of record). It first appeared online via AAAS at . Please refer to any applicable terms of use of the publisher.

    Final published version, 758 KB, PDF document

    Licence: CC BY


View research connections

Related faculties, schools or groups