Skip to content

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

Research output: Contribution to journalArticle (Academic Journal)

Standard

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display. / Vragniau, Charles; Bufton, Joshua C.; Garzoni, Frédéric; Stermann, Emilie; Rabi, Fruzsina; Terrat, Céline; Guidetti, Mélanie; Josserand, Véronique; Williams, Matt; Woods, Christopher J.; Viedma, Gerardo; Bates, Phil; Verrier, Bernard; Chaperot, Laurence; Schaffitzel, Christiane; Berger, Imre; Fender, Pascal.

In: Science Advances, Vol. 5, No. 9, eaaw2853, 25.09.2019.

Research output: Contribution to journalArticle (Academic Journal)

Harvard

Vragniau, C, Bufton, JC, Garzoni, F, Stermann, E, Rabi, F, Terrat, C, Guidetti, M, Josserand, V, Williams, M, Woods, CJ, Viedma, G, Bates, P, Verrier, B, Chaperot, L, Schaffitzel, C, Berger, I & Fender, P 2019, 'Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display', Science Advances, vol. 5, no. 9, eaaw2853. https://doi.org/10.1126/sciadv.aaw2853

APA

Vragniau, C., Bufton, J. C., Garzoni, F., Stermann, E., Rabi, F., Terrat, C., Guidetti, M., Josserand, V., Williams, M., Woods, C. J., Viedma, G., Bates, P., Verrier, B., Chaperot, L., Schaffitzel, C., Berger, I., & Fender, P. (2019). Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display. Science Advances, 5(9), [eaaw2853]. https://doi.org/10.1126/sciadv.aaw2853

Vancouver

Author

Vragniau, Charles ; Bufton, Joshua C. ; Garzoni, Frédéric ; Stermann, Emilie ; Rabi, Fruzsina ; Terrat, Céline ; Guidetti, Mélanie ; Josserand, Véronique ; Williams, Matt ; Woods, Christopher J. ; Viedma, Gerardo ; Bates, Phil ; Verrier, Bernard ; Chaperot, Laurence ; Schaffitzel, Christiane ; Berger, Imre ; Fender, Pascal. / Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display. In: Science Advances. 2019 ; Vol. 5, No. 9.

Bibtex

@article{b9bb8ae21b2c42d3a41756573db6ca5f,
title = "Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display",
abstract = "Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of multiple immunogenic epitopes from pathogens. We used cryo–electron microscopy at near-atomic resolution and implemented novel, cost-effective, high-performance cloud computing to reveal architectural features in unprecedented detail. We analyzed ADDomer interaction with components of the immune system and developed a promising first-in-kind ADDomer-based vaccine candidate to combat emerging Chikungunya infectious disease, exemplifying the potential of our approach.",
keywords = "SYNTHETIC BIOLOGY, minimal biology, Biodesign, Vaccine, advanced computing",
author = "Charles Vragniau and Bufton, {Joshua C.} and Fr{\'e}d{\'e}ric Garzoni and Emilie Stermann and Fruzsina Rabi and C{\'e}line Terrat and M{\'e}lanie Guidetti and V{\'e}ronique Josserand and Matt Williams and Woods, {Christopher J.} and Gerardo Viedma and Phil Bates and Bernard Verrier and Laurence Chaperot and Christiane Schaffitzel and Imre Berger and Pascal Fender",
year = "2019",
month = sep,
day = "25",
doi = "10.1126/sciadv.aaw2853",
language = "English",
volume = "5",
journal = "Science Advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "9",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

AU - Vragniau, Charles

AU - Bufton, Joshua C.

AU - Garzoni, Frédéric

AU - Stermann, Emilie

AU - Rabi, Fruzsina

AU - Terrat, Céline

AU - Guidetti, Mélanie

AU - Josserand, Véronique

AU - Williams, Matt

AU - Woods, Christopher J.

AU - Viedma, Gerardo

AU - Bates, Phil

AU - Verrier, Bernard

AU - Chaperot, Laurence

AU - Schaffitzel, Christiane

AU - Berger, Imre

AU - Fender, Pascal

PY - 2019/9/25

Y1 - 2019/9/25

N2 - Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of multiple immunogenic epitopes from pathogens. We used cryo–electron microscopy at near-atomic resolution and implemented novel, cost-effective, high-performance cloud computing to reveal architectural features in unprecedented detail. We analyzed ADDomer interaction with components of the immune system and developed a promising first-in-kind ADDomer-based vaccine candidate to combat emerging Chikungunya infectious disease, exemplifying the potential of our approach.

AB - Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of multiple immunogenic epitopes from pathogens. We used cryo–electron microscopy at near-atomic resolution and implemented novel, cost-effective, high-performance cloud computing to reveal architectural features in unprecedented detail. We analyzed ADDomer interaction with components of the immune system and developed a promising first-in-kind ADDomer-based vaccine candidate to combat emerging Chikungunya infectious disease, exemplifying the potential of our approach.

KW - SYNTHETIC BIOLOGY

KW - minimal biology

KW - Biodesign

KW - Vaccine

KW - advanced computing

UR - http://www.scopus.com/inward/record.url?scp=85072647810&partnerID=8YFLogxK

U2 - 10.1126/sciadv.aaw2853

DO - 10.1126/sciadv.aaw2853

M3 - Article (Academic Journal)

C2 - 31620562

AN - SCOPUS:85072647810

VL - 5

JO - Science Advances

JF - Science Advances

SN - 2375-2548

IS - 9

M1 - eaaw2853

ER -