Systematic Reviews of Diagnostic Test Accuracy

MMG Leeflang, JJ Deeks, C Gatsonis, PMM Bossuyt, B Aertgeerts, D Altman, G Antes, L Bachmann, H Buchner, P Bunting, F Buntinx, J Craig, R D'Amico, R de Vet, J Doust, M Egger, A Eisinga, G Fillipini, Y Flack-Ytter, A GlasP Glasziou, F Grossenbacher, R Harbord, J Hilden, L Hooft, H Horvath, C Hyde, L Irwig, M Kjeldstrøm, P Macaskill, S Mallett, R Mitchell, THM Moore, R Moustgaard, W Oosterhuis, M Pai, P Paliwal, D Pewsner, H Reitsma, J Riis, I Riphagen, A Rutjes, R Scholten, N Smidt, J Sterne, Y Takwoingi, D van der Windt, V Vlassov, J Watine, P Whiting

Research output: Contribution to journalArticle (Academic Journal)peer-review

912 Citations (Scopus)


More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic reviews of diagnostic test accuracy studies. Restrictive electronic search filters are discouraged, as is the use of summary quality scores. Methods for meta-analysis should take into account the paired nature of the estimates and their dependence on threshold. Authors of these reviews are advised to use the hierarchical summary receiver-operating characteristic or the bivariate model for the data analysis. Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research.
Translated title of the contributionSystematic Reviews of Diagnostic Test Accuracy
Original languageEnglish
Pages (from-to)889 - 897
Number of pages9
JournalAnnals of Internal Medicine
Volume149 (12)
Publication statusPublished - Dec 2008

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Title of Publication Reviewed: Systematic Reviews of Diagnostic Test Accuracy


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