T cell immunity to dengue virus and implications for vaccine design

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

Dengue virus infections are increasing at an alarming rate in many tropical and subtropical countries and represent, in some of these areas, a leading cause of hospitalization and death among children. The lack of a clear definition of the correlates of protection from severe dengue disease represents a major hurdle for vaccine development. In particular, the role of T lymphocytes during dengue infection remains unclear and there is evidence suggesting that these cells may be important for both protective immunity and/or immunopathology. In this review we discuss the findings that support a protective role of T cells versus those supporting their involvement in pathogenesis. A better understanding of T cell immunity is urgently needed for the development of safe and efficacious vaccines.

Original languageEnglish
Pages (from-to)443-53
Number of pages11
JournalExpert Review of Vaccines
Volume15
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Animals
  • Dengue/immunology
  • Dengue Vaccines/immunology
  • Dengue Virus/immunology
  • Disease Models, Animal
  • Drug Discovery/methods
  • Humans
  • T-Lymphocytes/immunology

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