Abstract
Dengue virus infections are increasing at an alarming rate in many tropical and subtropical countries and represent, in some of these areas, a leading cause of hospitalization and death among children. The lack of a clear definition of the correlates of protection from severe dengue disease represents a major hurdle for vaccine development. In particular, the role of T lymphocytes during dengue infection remains unclear and there is evidence suggesting that these cells may be important for both protective immunity and/or immunopathology. In this review we discuss the findings that support a protective role of T cells versus those supporting their involvement in pathogenesis. A better understanding of T cell immunity is urgently needed for the development of safe and efficacious vaccines.
Original language | English |
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Pages (from-to) | 443-53 |
Number of pages | 11 |
Journal | Expert Review of Vaccines |
Volume | 15 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2016 |
Keywords
- Animals
- Dengue/immunology
- Dengue Vaccines/immunology
- Dengue Virus/immunology
- Disease Models, Animal
- Drug Discovery/methods
- Humans
- T-Lymphocytes/immunology