Abstract
Addiction can be conceptualised as a disorder of maladaptive
learning and memory. Therefore, maladaptive drug memories
supporting drug-seeking and relapse behaviours may present
novel treatment targets for therapeutic approaches based
upon reconsolidation-blockade. It is known that different
structures within the limbic corticostriatal system contribute
differentially to different types of maladaptive drug memories,
including pavlovian associations between environmental cues
and contexts with the drug high, and instrumental memories
underlying drug-seeking. Here, we review the mechanisms
underlying drug memory reconsolidation in the amygdala,
striatum, and hippocampus, noting similarities and differences,
and opportunities for future research.
learning and memory. Therefore, maladaptive drug memories
supporting drug-seeking and relapse behaviours may present
novel treatment targets for therapeutic approaches based
upon reconsolidation-blockade. It is known that different
structures within the limbic corticostriatal system contribute
differentially to different types of maladaptive drug memories,
including pavlovian associations between environmental cues
and contexts with the drug high, and instrumental memories
underlying drug-seeking. Here, we review the mechanisms
underlying drug memory reconsolidation in the amygdala,
striatum, and hippocampus, noting similarities and differences,
and opportunities for future research.
| Original language | English |
|---|---|
| Pages (from-to) | 7-12 |
| Number of pages | 6 |
| Journal | Current Opinion in Pharmacology |
| Volume | 56 |
| Early online date | 19 Sept 2020 |
| DOIs | |
| Publication status | Published - 1 Feb 2021 |