Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

Catherine L. Tooke; Philip Hinchliffe; Michael Beer; Kirill Zinovjev; Charlotte K. Colenso; Christopher J. Schofield; Adrian J. Mulholland; James Spencer

doi:10.1101/2022.11.11.516172

Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer

Research output: Other contribution

Original language	Undefined/Unknown
DOIs	https://doi.org/10.1101/2022.11.11.516172
Publication status	Published - 11 Nov 2022

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Physical & Theoretical

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10.1101/2022.11.11.516172

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@misc{9f4ff064500c462ab0fd83aaa0e9c847,

title = "Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase",

author = "Tooke, \{Catherine L.\} and Philip Hinchliffe and Michael Beer and Kirill Zinovjev and Colenso, \{Charlotte K.\} and Schofield, \{Christopher J.\} and Mulholland, \{Adrian J.\} and James Spencer",

year = "2022",

month = nov,

day = "11",

doi = "10.1101/2022.11.11.516172",

language = "Undefined/Unknown",

type = "Other",

}

TY - GEN

T1 - Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

AU - Tooke, Catherine L.

AU - Hinchliffe, Philip

AU - Beer, Michael

AU - Zinovjev, Kirill

AU - Colenso, Charlotte K.

AU - Schofield, Christopher J.

AU - Mulholland, Adrian J.

AU - Spencer, James

PY - 2022/11/11

Y1 - 2022/11/11

UR - https://doi.org/10.1101/2022.11.11.516172

U2 - 10.1101/2022.11.11.516172

DO - 10.1101/2022.11.11.516172

M3 - Other contribution

ER -

Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

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HPC (High Performance Computing) and HTC (High Throughput Computing) Facilities

Cite this

Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

Research Groups and Themes

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Other files and links

Equipment

HPC (High Performance Computing) and HTC (High Throughput Computing) Facilities

Cite this