TCR clonotypes: molecular determinants of T-cell efficacy against HIV

Anya Lissina, Lisa A Chakrabarti, Masafumi Takiguchi, Victor Appay

Research output: Contribution to journalArticle (Academic Journal)peer-review

10 Citations (Scopus)
316 Downloads (Pure)

Abstract

Because of the enormous complexity and breadth of the overall HIV-specific CD8+ T-cell response, invaluable information regarding important aspects of T-cell efficacy against HIV can be sourced from studies performed on individual clonotypes. Data gathered from ex vivo and in vitro analyses of T-cell responses and viral evolution bring us one step closer towards deciphering the correlates of protection against HIV. HIV-responsive CD8+ T-cell populations are characterized by specific clonotypic immunodominance patterns and public TCRs. The TCR endows T-cells with two key features, important for the effective control of HIV: avidity and crossreactivity. While TCR avidity is a major determinant of CD8+ T-cell functional efficacy against the virus, crossreactivity towards wildtype and mutant viral epitopes is crucial for adaptation to HIV evolution. The properties of CD4+ T-cell responses in HIV controllers appear also to be shaped by high avidity public TCR clonotypes. The molecular nature of the TCR, together with the clonotypic composition of the HIV-specific T-cell response, emerge as major determinants of anti-viral efficacy.
Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalCurrent Opinion in Virology
Volume16
Issue numberViral immunology
Early online date12 Feb 2016
DOIs
Publication statusPublished - Feb 2016

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