Testing replication of a 5-SNP set for general cognitive ability in six population samples

Michelle Luciano; Penelope A. Lind; Ian J. Deary; Antony Payton; Danielle Posthuma; Lee M. Butcher; Zoltan Bochdanovits; Lawrence J. Whalley; Peter M. Visscher; Sarah E. Harris; Tinca J C Polderman; Oliver S P Davis; Margaret J. Wright; John M. Starr; Eco J C de Geus; Timothy C. Bates; Grant W. Montgomery; Dorret I. Boomsma; Nicholas G. Martin; Robert Plomin

doi:10.1038/ejhg.2008.100

Testing replication of a 5-SNP set for general cognitive ability in six population samples

Michelle Luciano^*, Penelope A. Lind, Ian J. Deary, Antony Payton, Danielle Posthuma, Lee M. Butcher, Zoltan Bochdanovits, Lawrence J. Whalley, Peter M. Visscher, Sarah E. Harris, Tinca J C Polderman, Oliver S P Davis, Margaret J. Wright, John M. Starr, Eco J C de Geus, Timothy C. Bates, Grant W. Montgomery, Dorret I. Boomsma, Nicholas G. Martin, Robert Plomin

^*Corresponding author for this work

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

8 Citations (Scopus)

Abstract

A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P = 0.06) in the direction of the original finding, but results from the other samples (N = 205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P = 0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied.

Original language	English
Pages (from-to)	1388-1395
Number of pages	8
Journal	European Journal of Human Genetics
Volume	16
Issue number	11
DOIs	https://doi.org/10.1038/ejhg.2008.100
Publication status	Published - 24 Jul 2008

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Luciano, M., Lind, P. A., Deary, I. J., Payton, A., Posthuma, D., Butcher, L. M., Bochdanovits, Z., Whalley, L. J., Visscher, P. M., Harris, S. E., Polderman, T. J. C., Davis, O. S. P., Wright, M. J., Starr, J. M., de Geus, E. J. C., Bates, T. C., Montgomery, G. W., Boomsma, D. I., Martin, N. G., & Plomin, R. (2008). Testing replication of a 5-SNP set for general cognitive ability in six population samples. European Journal of Human Genetics, 16(11), 1388-1395. https://doi.org/10.1038/ejhg.2008.100

Luciano, Michelle ; Lind, Penelope A. ; Deary, Ian J. ; Payton, Antony ; Posthuma, Danielle ; Butcher, Lee M. ; Bochdanovits, Zoltan ; Whalley, Lawrence J. ; Visscher, Peter M. ; Harris, Sarah E. ; Polderman, Tinca J C ; Davis, Oliver S P ; Wright, Margaret J. ; Starr, John M. ; de Geus, Eco J C ; Bates, Timothy C. ; Montgomery, Grant W. ; Boomsma, Dorret I. ; Martin, Nicholas G. ; Plomin, Robert. / Testing replication of a 5-SNP set for general cognitive ability in six population samples. In: European Journal of Human Genetics. 2008 ; Vol. 16, No. 11. pp. 1388-1395.

@article{dcf2f9bcead744abbab453ecf7e1045a,

title = "Testing replication of a 5-SNP set for general cognitive ability in six population samples",

abstract = "A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P = 0.06) in the direction of the original finding, but results from the other samples (N = 205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P = 0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied.",

author = "Michelle Luciano and Lind, {Penelope A.} and Deary, {Ian J.} and Antony Payton and Danielle Posthuma and Butcher, {Lee M.} and Zoltan Bochdanovits and Whalley, {Lawrence J.} and Visscher, {Peter M.} and Harris, {Sarah E.} and Polderman, {Tinca J C} and Davis, {Oliver S P} and Wright, {Margaret J.} and Starr, {John M.} and {de Geus}, {Eco J C} and Bates, {Timothy C.} and Montgomery, {Grant W.} and Boomsma, {Dorret I.} and Martin, {Nicholas G.} and Robert Plomin",

year = "2008",

month = jul,

day = "24",

doi = "10.1038/ejhg.2008.100",

language = "English",

volume = "16",

pages = "1388--1395",

journal = "European Journal of Human Genetics",

issn = "1018-4813",

publisher = "Springer Nature",

number = "11",

}

Luciano, M, Lind, PA, Deary, IJ, Payton, A, Posthuma, D, Butcher, LM, Bochdanovits, Z, Whalley, LJ, Visscher, PM, Harris, SE, Polderman, TJC, Davis, OSP, Wright, MJ, Starr, JM, de Geus, EJC, Bates, TC, Montgomery, GW, Boomsma, DI, Martin, NG & Plomin, R 2008, 'Testing replication of a 5-SNP set for general cognitive ability in six population samples', European Journal of Human Genetics, vol. 16, no. 11, pp. 1388-1395. https://doi.org/10.1038/ejhg.2008.100

Testing replication of a 5-SNP set for general cognitive ability in six population samples. / Luciano, Michelle; Lind, Penelope A.; Deary, Ian J.; Payton, Antony; Posthuma, Danielle; Butcher, Lee M.; Bochdanovits, Zoltan; Whalley, Lawrence J.; Visscher, Peter M.; Harris, Sarah E.; Polderman, Tinca J C; Davis, Oliver S P; Wright, Margaret J.; Starr, John M.; de Geus, Eco J C; Bates, Timothy C.; Montgomery, Grant W.; Boomsma, Dorret I.; Martin, Nicholas G.; Plomin, Robert.

In: European Journal of Human Genetics, Vol. 16, No. 11, 24.07.2008, p. 1388-1395.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Testing replication of a 5-SNP set for general cognitive ability in six population samples

AU - Luciano, Michelle

AU - Lind, Penelope A.

AU - Deary, Ian J.

AU - Payton, Antony

AU - Posthuma, Danielle

AU - Butcher, Lee M.

AU - Bochdanovits, Zoltan

AU - Whalley, Lawrence J.

AU - Visscher, Peter M.

AU - Harris, Sarah E.

AU - Polderman, Tinca J C

AU - Davis, Oliver S P

AU - Wright, Margaret J.

AU - Starr, John M.

AU - de Geus, Eco J C

AU - Bates, Timothy C.

AU - Montgomery, Grant W.

AU - Boomsma, Dorret I.

AU - Martin, Nicholas G.

AU - Plomin, Robert

PY - 2008/7/24

Y1 - 2008/7/24

N2 - A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P = 0.06) in the direction of the original finding, but results from the other samples (N = 205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P = 0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied.

AB - A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P = 0.06) in the direction of the original finding, but results from the other samples (N = 205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P = 0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied.

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U2 - 10.1038/ejhg.2008.100

DO - 10.1038/ejhg.2008.100

M3 - Article (Academic Journal)

C2 - 18493267

AN - SCOPUS:54549108915

VL - 16

SP - 1388

EP - 1395

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

SN - 1018-4813

IS - 11

ER -

Testing replication of a 5-SNP set for general cognitive ability in six population samples

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