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TFEB controls retromer expression in response to nutrient availability

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TFEB controls retromer expression in response to nutrient availability. / Curnock, Rachel; Calcagni, Alessia; Ballabio, Andrea; Cullen, Peter J.

In: Journal of Cell Biology, Vol. 218, No. 12, 06.11.2019, p. 3954-3966.

Research output: Contribution to journalArticle

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Curnock, R, Calcagni, A, Ballabio, A & Cullen, PJ 2019, 'TFEB controls retromer expression in response to nutrient availability', Journal of Cell Biology, vol. 218, no. 12, pp. 3954-3966. https://doi.org/10.1083/jcb.201903006

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Curnock, Rachel ; Calcagni, Alessia ; Ballabio, Andrea ; Cullen, Peter J. / TFEB controls retromer expression in response to nutrient availability. In: Journal of Cell Biology. 2019 ; Vol. 218, No. 12. pp. 3954-3966.

Bibtex

@article{0e3bed04f96e4361ae1e0ba976f979ed,
title = "TFEB controls retromer expression in response to nutrient availability",
abstract = "Endosomal recycling maintains the cell surface abundance of nutrient transporters for nutrient uptake, but how the cell integrates nutrient availability with recycling is less well understood. Here, in studying the recycling of human glutamine transporters ASCT2 (SLC1A5), LAT1 (SLC7A5), SNAT1 (SLC38A1), and SNAT2 (SLC38A2), we establish that following amino acid restriction, the adaptive delivery of SNAT2 to the cell surface relies on retromer, a master conductor of endosomal recycling. Upon complete amino acid starvation or selective glutamine depletion, we establish that retromer expression is upregulated by transcription factor EB (TFEB) and other members of the MiTF/TFE family of transcription factors through association with CLEAR elements in the promoters of the retromer genes VPS35 and VPS26A TFEB regulation of retromer expression therefore supports adaptive nutrient acquisition through endosomal recycling.",
keywords = "glutamine, membrane transport proteins, nutrients, staarvation, amino acids, mitf protein, sorting, transcription factor, genes, oncogenes",
author = "Rachel Curnock and Alessia Calcagni and Andrea Ballabio and Cullen, {Peter J.}",
year = "2019",
month = "11",
day = "6",
doi = "10.1083/jcb.201903006",
language = "English",
volume = "218",
pages = "3954--3966",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "12",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - TFEB controls retromer expression in response to nutrient availability

AU - Curnock, Rachel

AU - Calcagni, Alessia

AU - Ballabio, Andrea

AU - Cullen, Peter J.

PY - 2019/11/6

Y1 - 2019/11/6

N2 - Endosomal recycling maintains the cell surface abundance of nutrient transporters for nutrient uptake, but how the cell integrates nutrient availability with recycling is less well understood. Here, in studying the recycling of human glutamine transporters ASCT2 (SLC1A5), LAT1 (SLC7A5), SNAT1 (SLC38A1), and SNAT2 (SLC38A2), we establish that following amino acid restriction, the adaptive delivery of SNAT2 to the cell surface relies on retromer, a master conductor of endosomal recycling. Upon complete amino acid starvation or selective glutamine depletion, we establish that retromer expression is upregulated by transcription factor EB (TFEB) and other members of the MiTF/TFE family of transcription factors through association with CLEAR elements in the promoters of the retromer genes VPS35 and VPS26A TFEB regulation of retromer expression therefore supports adaptive nutrient acquisition through endosomal recycling.

AB - Endosomal recycling maintains the cell surface abundance of nutrient transporters for nutrient uptake, but how the cell integrates nutrient availability with recycling is less well understood. Here, in studying the recycling of human glutamine transporters ASCT2 (SLC1A5), LAT1 (SLC7A5), SNAT1 (SLC38A1), and SNAT2 (SLC38A2), we establish that following amino acid restriction, the adaptive delivery of SNAT2 to the cell surface relies on retromer, a master conductor of endosomal recycling. Upon complete amino acid starvation or selective glutamine depletion, we establish that retromer expression is upregulated by transcription factor EB (TFEB) and other members of the MiTF/TFE family of transcription factors through association with CLEAR elements in the promoters of the retromer genes VPS35 and VPS26A TFEB regulation of retromer expression therefore supports adaptive nutrient acquisition through endosomal recycling.

KW - glutamine

KW - membrane transport proteins

KW - nutrients

KW - staarvation

KW - amino acids

KW - mitf protein

KW - sorting

KW - transcription factor

KW - genes

KW - oncogenes

UR - http://www.scopus.com/inward/record.url?scp=85075481760&partnerID=8YFLogxK

U2 - 10.1083/jcb.201903006

DO - 10.1083/jcb.201903006

M3 - Article

VL - 218

SP - 3954

EP - 3966

JO - Journal of Cell Biology

JF - Journal of Cell Biology

SN - 0021-9525

IS - 12

ER -