TGF-β signal transduction in oro-facial health and non-malignant disease (Part I)

SS Prime, M Pring, M Davies, IC Paterson

Research output: Contribution to journalArticle (Academic Journal)peer-review

52 Citations (Scopus)

Abstract

The transforming growth factor-beta (TGF-beta) family of cytokines consists of multi-functional polypeptides that regulate a variety of cell processes, including proliferation, differentiation, apoptosis, extracellular matrix elaboration, angiogenesis, and immune suppression, among others. In so doing, TGF-beta plays a key role in the control of cell behavior in both health and disease. In this report, we review what is known about the mechanisms of activation of the peptide, together with details of TGF-beta signal transduction pathways. This review summarizes the evidence implicating TGF-beta in normal physiological processes of the craniofacial complex-such as palatogenesis, tooth formation, wound healing, and scarring-and then evaluates its role in non-malignant disease processes such as scleroderma, submucous fibrosis, periodontal disease, and lichen planus.
Translated title of the contributionTGF-β signal transduction in oro-facial health and non-malignant disease (Part I)
Original languageEnglish
Pages (from-to)324 - 336
Number of pages13
JournalCritical Reviews in Oral Biology & Medicine
Volume15
Publication statusPublished - Nov 2004

Bibliographical note

Publisher: International and American Associations for Dental Research

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