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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Research output: Contribution to journalArticle

  • Thomas G. Bird
  • Mirya M ller
  • Luk Boulter
  • David F. Vincent
  • Rachel A. Ridgway
  • Elen Lopez-Guadamillas
  • Wei Yu Lu
  • Thoma Jamieson
  • Olivie Govaere
  • Andrew D. Campbell
  • Sof Ferreira-Gonzalez
  • Alicia M. Cole
  • Trevo Hay
  • Kenneth J. Simpson
  • Willia Clark
  • An Hedley
  • Mair Clarke
  • Paulin Gentaz
  • Coli Nixon
  • Steve Bryce
  • Christo Kiourtis
  • Joe Sprangers
  • Robert J. Nibbs
  • Nico Van Rooijen
  • Lauren Bartholin
  • Steven R. McGreal
  • Udaya Apte
  • Simon T. Barry
  • John P. Iredalehttp://orcid.org/0000-0003-2174-5127
  • Alan R. Clarke
  • Manue Serrano
  • Tania A. Roskams
  • Owen J. Sansom
  • Stuart J. Forbes
Original languageEnglish
Article numbereaan1230
JournalScience Translational Medicine
Volume10
Issue number454
DOIs
DateAccepted/In press - 13 Mar 2018
DatePublished (current) - 15 Aug 2018

Abstract

Liver injury results in rapid regeneration through hepatocyte proliferation and hypertrophy. However, after acute severe injury, such as acetaminophen poisoning, effective regeneration may fail. We investigated how senescence may underlie this regenerative failure. In human acute liver disease, and murine models, p21-dependent hepatocellular senescence was proportionate to disease severity and was associated with impaired regeneration. In an acetaminophen injury mouse model, a transcriptional signature associated with the induction of paracrine senescence was observed within 24 hours and was followed by one of impaired proliferation. In mouse genetic models of hepatocyte injury and senescence, we observed transmission of senescence to local uninjured hepatocytes. Spread of senescence depended on macrophage-derived transforming growth factor β1 (TGFβ1) ligand. In acetaminophen poisoning, inhibition of TGFβ receptor 1 (TGFβR1) improved mouse survival. TGFβR1 inhibition reduced senescence and enhanced liver regeneration even when delivered beyond the therapeutic window for treating acetaminophen poisoning. This mechanism, in which injury-induced senescence impairs liver regeneration, is an attractive therapeutic target for developing treatments for acute liver failure.

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