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The 1980s: d-AP5, LTP and a Decade of NMDA Receptor Discoveries

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The 1980s : d-AP5, LTP and a Decade of NMDA Receptor Discoveries. / Lodge, David; Watkins, Jeffrey C; Bortolotto, Zuner; Jane, David; Volianskis, Arturas.

In: Neurochemical Research, Vol. 44, No. 3, 01.03.2019, p. 516-530.

Research output: Contribution to journalArticle

Harvard

Lodge, D, Watkins, JC, Bortolotto, Z, Jane, D & Volianskis, A 2019, 'The 1980s: d-AP5, LTP and a Decade of NMDA Receptor Discoveries', Neurochemical Research, vol. 44, no. 3, pp. 516-530. https://doi.org/10.1007/s11064-018-2640-6

APA

Lodge, D., Watkins, J. C., Bortolotto, Z., Jane, D., & Volianskis, A. (2019). The 1980s: d-AP5, LTP and a Decade of NMDA Receptor Discoveries. Neurochemical Research, 44(3), 516-530. https://doi.org/10.1007/s11064-018-2640-6

Vancouver

Lodge D, Watkins JC, Bortolotto Z, Jane D, Volianskis A. The 1980s: d-AP5, LTP and a Decade of NMDA Receptor Discoveries. Neurochemical Research. 2019 Mar 1;44(3):516-530. https://doi.org/10.1007/s11064-018-2640-6

Author

Lodge, David ; Watkins, Jeffrey C ; Bortolotto, Zuner ; Jane, David ; Volianskis, Arturas. / The 1980s : d-AP5, LTP and a Decade of NMDA Receptor Discoveries. In: Neurochemical Research. 2019 ; Vol. 44, No. 3. pp. 516-530.

Bibtex

@article{6251184c18214e188f796857170c5e83,
title = "The 1980s: d-AP5, LTP and a Decade of NMDA Receptor Discoveries",
abstract = "In the 1960s and 70s, biochemical and pharmacological evidence was pointing toward glutamate as a synaptic transmitter at a number of distinct receptor classes, known as NMDA and non-NMDA receptors. The field, however, lacked a potent and highly selective antagonist to block these putative postsynaptic receptors. So, the discoveries in the early 1980s of D-AP5 as a selective NMDA receptor antagonist and of its ability to block synaptic events and plasticity were a major breakthrough leading to an explosion of knowledge about this receptor subtype. During the next 10 years, the role of NMDA receptors was established in synaptic transmission, long-term potentiation, learning and memory, epilepsy, pain, among others. Hints at pharmacological heterogeneity among NMDA receptors were followed by the cloning of separate subunits. The purpose of this review is to recognize the important contributions made in the 1980s by Graham L. Collingridge and other key scientists to the advances in our understanding of the functions of NMDA receptors throughout the central nervous system.",
keywords = "Long-term potentiation (LTP), NMDA, NMDA receptors, APV, d-AP5, Synaptic plasticity",
author = "David Lodge and Watkins, {Jeffrey C} and Zuner Bortolotto and David Jane and Arturas Volianskis",
year = "2019",
month = "3",
day = "1",
doi = "10.1007/s11064-018-2640-6",
language = "English",
volume = "44",
pages = "516--530",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer US",
number = "3",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - The 1980s

T2 - d-AP5, LTP and a Decade of NMDA Receptor Discoveries

AU - Lodge, David

AU - Watkins, Jeffrey C

AU - Bortolotto, Zuner

AU - Jane, David

AU - Volianskis, Arturas

PY - 2019/3/1

Y1 - 2019/3/1

N2 - In the 1960s and 70s, biochemical and pharmacological evidence was pointing toward glutamate as a synaptic transmitter at a number of distinct receptor classes, known as NMDA and non-NMDA receptors. The field, however, lacked a potent and highly selective antagonist to block these putative postsynaptic receptors. So, the discoveries in the early 1980s of D-AP5 as a selective NMDA receptor antagonist and of its ability to block synaptic events and plasticity were a major breakthrough leading to an explosion of knowledge about this receptor subtype. During the next 10 years, the role of NMDA receptors was established in synaptic transmission, long-term potentiation, learning and memory, epilepsy, pain, among others. Hints at pharmacological heterogeneity among NMDA receptors were followed by the cloning of separate subunits. The purpose of this review is to recognize the important contributions made in the 1980s by Graham L. Collingridge and other key scientists to the advances in our understanding of the functions of NMDA receptors throughout the central nervous system.

AB - In the 1960s and 70s, biochemical and pharmacological evidence was pointing toward glutamate as a synaptic transmitter at a number of distinct receptor classes, known as NMDA and non-NMDA receptors. The field, however, lacked a potent and highly selective antagonist to block these putative postsynaptic receptors. So, the discoveries in the early 1980s of D-AP5 as a selective NMDA receptor antagonist and of its ability to block synaptic events and plasticity were a major breakthrough leading to an explosion of knowledge about this receptor subtype. During the next 10 years, the role of NMDA receptors was established in synaptic transmission, long-term potentiation, learning and memory, epilepsy, pain, among others. Hints at pharmacological heterogeneity among NMDA receptors were followed by the cloning of separate subunits. The purpose of this review is to recognize the important contributions made in the 1980s by Graham L. Collingridge and other key scientists to the advances in our understanding of the functions of NMDA receptors throughout the central nervous system.

KW - Long-term potentiation (LTP)

KW - NMDA

KW - NMDA receptors

KW - APV

KW - d-AP5

KW - Synaptic plasticity

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U2 - 10.1007/s11064-018-2640-6

DO - 10.1007/s11064-018-2640-6

M3 - Article

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AN - SCOPUS:85054586710

VL - 44

SP - 516

EP - 530

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 3

ER -