The adaptive immune system in diseases of the central nervous system

David C Wraith, Lindsay B Nicholson

Research output: Contribution to journalArticle (Academic Journal)peer-review

54 Citations (Scopus)

Abstract

Tissues of the CNS, such as the brain, optic nerves, and spinal cord, may be affected by a range of insults including genetic, autoimmune, infectious, or neurodegenerative diseases and cancer. The immune system is involved in the pathogenesis of many of these, either by causing tissue damage or alternatively by responding to disease and contributing to repair. It is clearly vital that cells of the immune system patrol the CNS and protect against infection. However, in contrast to other tissues, damage caused by immune pathology in the CNS can be irreparable. The nervous and immune systems have, therefore, coevolved to permit effective immune surveillance while limiting immune pathology. Here we will consider aspects of adaptive immunity in the CNS and the retina, both in the context of protection from infection as well as cancer and autoimmunity, while focusing on immune responses that compromise health and lead to significant morbidity.
Original languageEnglish
Pages (from-to)1172-1179
Number of pages8
JournalJournal of Clinical Investigation
Volume122
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
  • PARANEOPLASTIC CEREBELLAR DEGENERATION
  • ALTERED PEPTIDE LIGAND
  • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
  • STIFF-PERSON SYNDROME
  • MYELIN BASIC-PROTEIN
  • T-CELL-ACTIVATION
  • MULTIPLE-SCLEROSIS
  • NEUROMYELITIS-OPTICA
  • DENDRITIC CELLS

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