The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

Thomas Kuri; Klara K Eriksson; Akos Putics; Roland Züst; Eric J Snijder; Andrew D Davidson; Stuart G Siddell; Volker Thiel; John Ziebuhr; Friedemann Weber

doi:10.1099/vir.0.031856-0

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

Thomas Kuri, Klara K Eriksson, Akos Putics, Roland Züst, Eric J Snijder, Andrew D Davidson, Stuart G Siddell, Volker Thiel, John Ziebuhr, Friedemann Weber

Research output: Contribution to journal › Article (Academic Journal) › peer-review

82 Citations (Scopus)

Abstract

Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.

Original language	English
Pages (from-to)	1899-905
Number of pages	7
Journal	Journal of General Virology
Volume	92
Issue number	Pt 8
DOIs	https://doi.org/10.1099/vir.0.031856-0
Publication status	Published - Aug 2011

Keywords

Amino Acid Sequence
Antiviral Agents
Cell Line
Coronavirus 229E, Human
Coronavirus Infections
Humans
Interferon-alpha
Molecular Sequence Data
Phosphoric Monoester Hydrolases
Protein Structure, Tertiary
SARS Virus
Sequence Alignment
Severe Acute Respiratory Syndrome
Viral Proteins

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Kuri, T., Eriksson, K. K., Putics, A., Züst, R., Snijder, E. J., Davidson, A. D., Siddell, S. G., Thiel, V., Ziebuhr, J., & Weber, F. (2011). The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses. Journal of General Virology, 92(Pt 8), 1899-905. https://doi.org/10.1099/vir.0.031856-0

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title = "The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses",

abstract = "Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.",

keywords = "Amino Acid Sequence, Antiviral Agents, Cell Line, Coronavirus 229E, Human, Coronavirus Infections, Humans, Interferon-alpha, Molecular Sequence Data, Phosphoric Monoester Hydrolases, Protein Structure, Tertiary, SARS Virus, Sequence Alignment, Severe Acute Respiratory Syndrome, Viral Proteins",

author = "Thomas Kuri and Eriksson, {Klara K} and Akos Putics and Roland Z{\"u}st and Snijder, {Eric J} and Davidson, {Andrew D} and Siddell, {Stuart G} and Volker Thiel and John Ziebuhr and Friedemann Weber",

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Kuri, T, Eriksson, KK, Putics, A, Züst, R, Snijder, EJ, Davidson, AD, Siddell, SG, Thiel, V, Ziebuhr, J & Weber, F 2011, 'The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses', Journal of General Virology, vol. 92, no. Pt 8, pp. 1899-905. https://doi.org/10.1099/vir.0.031856-0

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses. / Kuri, Thomas; Eriksson, Klara K; Putics, Akos et al.
In: Journal of General Virology, Vol. 92, No. Pt 8, 08.2011, p. 1899-905.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AB - Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.

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KW - Cell Line

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KW - Coronavirus Infections

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KW - Interferon-alpha

KW - Molecular Sequence Data

KW - Phosphoric Monoester Hydrolases

KW - Protein Structure, Tertiary

KW - SARS Virus

KW - Sequence Alignment

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ER -

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

Abstract

Keywords

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