The antibacterial efficacy of a foam mouthwash and its ability to remove biofilms

Sian B Jones, Nicola West, Pavel Nesmiyanov, Sergey Krylov, Vera Klechkovskaya, Natalya Arkharova, Vladimir Plakunov, Svetlana Zakirova

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)
315 Downloads (Pure)


Objectives/Aims: To evaluate the antimicrobial activity of a newly developed foam mouthwash containing a modified lactoperoxidase system in vitro.

Materials and Methods: Biofilms of five bacterial species were developed on hydrophobic and hydrophilic surfaces whilst salivary based biofilm was grown on tooth enamel. Each surface was exposed to the foam mouthwash or saline in vitro. Optical density and Scanning Electron Microscopy (SEM) was used to determine retention of the biofilm following 5 second or 30 second exposure time.

Results: The foam mouthwash was active against biofilms formed by S. aureus, K. rhizophila, M. thailandicus, E. coli and C. violaceum and eliminated significant amount of biofilm from each surface; immature 4 hour biofilm was less resistant than 24 hour biofilm. A 30 seconds rinse showed best performance, with removal of up to 66% of biofilm from the hydrophilic surface. SEM imaging confirmed oral biofilm removal from the enamel surface after a 5 second rinse with the foam mouthwash.

Discussion: Foam mouthwash demonstrated a significant impact on growing biofilm when compared against saline solution. Growing biofilms were more susceptible to the action of the foam mouthwash, which justifies after-meal use of the mouthwash when traditional dentifrices may not be accessible.

Conclusion: Foam mouthwash can be a convenient on-the-go format of oral care products that can be used after meals or when needed to reduce the risk of biofilm-associated oral conditions
Original languageEnglish
Article number17038
Number of pages5
JournalBDJ Open
Early online date27 Sept 2018
Publication statusE-pub ahead of print - 27 Sept 2018


  • Oral bacteria
  • mouthwash
  • foam
  • biofilm
  • dentifrice


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