The Arabidopsis circadian clock incorporates a cADPR-based feedback loop

Antony N. Dodd; Michael J. Gardner; Carlos T. Hotta; Katharine E. Hubbard; Neil Dalchau; John Love; Jean-Maurice Assie; Fiona C. Robertson; Mia Kyed Jakobsen; Jorge Goncalves; Dale Sanders; Alex A. R. Webb

doi:10.1126/science.1146757

The Arabidopsis circadian clock incorporates a cADPR-based feedback loop

Antony N. Dodd, Michael J. Gardner, Carlos T. Hotta, Katharine E. Hubbard, Neil Dalchau, John Love, Jean-Maurice Assie, Fiona C. Robertson, Mia Kyed Jakobsen, Jorge Goncalves, Dale Sanders, Alex A. R. Webb

Research output: Contribution to journal › Article (Academic Journal) › peer-review

154 Citations (Scopus)

Abstract

Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.

Original language	English
Pages (from-to)	1789-1792
Number of pages	4
Journal	Science
Volume	318
Issue number	5857
DOIs	https://doi.org/10.1126/science.1146757
Publication status	Published - 14 Dec 2007

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10.1126/science.1146757

Cite this

@article{3096aeb5fb4b470da435c2a299e9fba3,

title = "The Arabidopsis circadian clock incorporates a cADPR-based feedback loop",

abstract = "Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.",

author = "Dodd, {Antony N.} and Gardner, {Michael J.} and Hotta, {Carlos T.} and Hubbard, {Katharine E.} and Neil Dalchau and John Love and Jean-Maurice Assie and Robertson, {Fiona C.} and Jakobsen, {Mia Kyed} and Jorge Goncalves and Dale Sanders and Webb, {Alex A. R.}",

year = "2007",

month = dec,

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doi = "10.1126/science.1146757",

language = "English",

volume = "318",

pages = "1789--1792",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5857",

}

The Arabidopsis circadian clock incorporates a cADPR-based feedback loop. / Dodd, Antony N.; Gardner, Michael J.; Hotta, Carlos T.; Hubbard, Katharine E.; Dalchau, Neil; Love, John; Assie, Jean-Maurice; Robertson, Fiona C.; Jakobsen, Mia Kyed; Goncalves, Jorge; Sanders, Dale; Webb, Alex A. R.

In: Science, Vol. 318, No. 5857, 14.12.2007, p. 1789-1792.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - The Arabidopsis circadian clock incorporates a cADPR-based feedback loop

AU - Dodd, Antony N.

AU - Gardner, Michael J.

AU - Hotta, Carlos T.

AU - Hubbard, Katharine E.

AU - Dalchau, Neil

AU - Love, John

AU - Assie, Jean-Maurice

AU - Robertson, Fiona C.

AU - Jakobsen, Mia Kyed

AU - Goncalves, Jorge

AU - Sanders, Dale

AU - Webb, Alex A. R.

PY - 2007/12/14

Y1 - 2007/12/14

N2 - Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.

AB - Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.

U2 - 10.1126/science.1146757

DO - 10.1126/science.1146757

M3 - Article (Academic Journal)

VL - 318

SP - 1789

EP - 1792

JO - Science

JF - Science

SN - 0036-8075

IS - 5857

ER -