The Arabidopsis circadian clock incorporates a cADPR-based feedback loop

Antony N. Dodd, Michael J. Gardner, Carlos T. Hotta, Katharine E. Hubbard, Neil Dalchau, John Love, Jean-Maurice Assie, Fiona C. Robertson, Mia Kyed Jakobsen, Jorge Goncalves, Dale Sanders, Alex A. R. Webb

Research output: Contribution to journalArticle (Academic Journal)peer-review

154 Citations (Scopus)


Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.

Original languageEnglish
Pages (from-to)1789-1792
Number of pages4
Issue number5857
Publication statusPublished - 14 Dec 2007

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