The ascent of man(made oxidoreductases)

Katie Grayson, Ross Anderson

Research output: Contribution to journalReview article (Academic Journal)peer-review

14 Citations (Scopus)
259 Downloads (Pure)


Though established 40 years ago, the field of de novo protein design has recently come of age, with new designs exhibiting an unprecedented level of sophistication in structure and function. With respect to catalysis, de novo enzymes promise to revolutionise the industrial production of useful chemicals and materials, while providing new biomolecules as plug-and-play components in the metabolic pathways of living cells. To this end, there are now de novo metalloenzymes that are assembled in vivo, including the recently reported C45 maquette, which can catalyse a variety of substrate oxidations with efficiencies rivalling those of closely related natural enzymes. Here we explore the successful design of this de novo enzyme, which was designed to minimise the undesirable complexity of natural proteins using a minimalistic bottom-up approach.
Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalCurrent Opinion in Structural Biology
Early online date10 May 2018
Publication statusPublished - Aug 2018

Structured keywords

  • BrisSynBio
  • Bristol BioDesign Institute


  • Synthetic Biology


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