Projects per year
Abstract
Though established 40 years ago, the field of de novo protein design has recently come of age, with new designs exhibiting an unprecedented level of sophistication in structure and function. With respect to catalysis, de novo enzymes promise to revolutionise the industrial production of useful chemicals and materials, while providing new biomolecules as plug-and-play components in the metabolic pathways of living cells. To this end, there are now de novo metalloenzymes that are assembled in vivo, including the recently reported C45 maquette, which can catalyse a variety of substrate oxidations with efficiencies rivalling those of closely related natural enzymes. Here we explore the successful design of this de novo enzyme, which was designed to minimise the undesirable complexity of natural proteins using a minimalistic bottom-up approach.
Original language | English |
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Pages (from-to) | 149-155 |
Number of pages | 7 |
Journal | Current Opinion in Structural Biology |
Volume | 51 |
Early online date | 10 May 2018 |
DOIs | |
Publication status | Published - Aug 2018 |
Research Groups and Themes
- BrisSynBio
- Bristol BioDesign Institute
Keywords
- Synthetic Biology
Fingerprint
Dive into the research topics of 'The ascent of man(made oxidoreductases)'. Together they form a unique fingerprint.Projects
- 2 Finished
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Building a Solar-Powered, Carbon-Fixing Protoalgae
Anderson, J. L. R. (Principal Investigator)
2/11/15 → 1/11/18
Project: Research
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BrisSynBio: Bristol Centre for Synthetic Biology
Woolfson, D. N. (Principal Investigator)
31/07/14 → 31/03/22
Project: Research