The Assembly Line Enzymology of Polyketide Biosynthesis

Paul Race, Marisa Till

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

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Abstract

Polyketides are a structurally and functionally diverse family of bioactive natural products that have found widespread application as pharmaceuticals, agrochemicals, and veterinary medicines. In bacteria complex polyketides are biosynthesized by giant multifunctional megaenzymes, termed modular polyketide synthases (PKSs), which construct their products in a highly coordinated assembly line-like fashion from a pool of simple precursor substrates. Not only is the multifaceted enzymology of PKSs a fascinating target for study, but it also presents considerable opportunities for the reengineering of these systems affording access to functionally optimized unnatural natural products. Here we provide an introductory primer to modular polyketide synthase structure and function, and highlight recent advances in the characterization and exploitation of these systems.
Original languageEnglish
Title of host publicationNonribosomal Peptide and Polyketide Biosynthesis
Subtitle of host publicationMethods and Protocols
EditorsBradley S Evans
PublisherSpringer
Pages31-49
Number of pages19
ISBN (Electronic)9781493933754
ISBN (Print)9781493933730
DOIs
Publication statusPublished - Feb 2016

Publication series

NameMethods in Molecular Biology
PublisherSpringer
Volume1401
ISSN (Print)1064-3745

Structured keywords

  • Bristol BioDesign Institute
  • BrisSynBio

Keywords

  • synthetic biology

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