The Association Between APOE ε4 and Alzheimer-type Dementia among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study

Angelique P A Vermeiren; Hans Bosma; Pieter-Jelle Visser; Maurice P Zeegers; Caroline Graff; Michael Ewers; Giovanni B Frisoni; Lutz Frölich; Harald Hampel; Roy W Jones; Patrick G Kehoe; Hermine Lenoir; Lennart Minthon; Flavio M Nobili; Marcel Olde Rikkert; Anne-Sophie Rigaud; Philip Scheltens; Hilkka Soininen; Luiza Spiru; Magda Tsolaki; Lars-Olof Wahlund; Bruno Vellas; Gordon Wilcock; Lyzel S Elias-Sonnenschein; Frans R J Verhey

doi:10.3233/JAD-122182

The Association Between APOE ε4 and Alzheimer-type Dementia among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study

Angelique P A Vermeiren, Hans Bosma, Pieter-Jelle Visser, Maurice P Zeegers, Caroline Graff, Michael Ewers, Giovanni B Frisoni, Lutz Frölich, Harald Hampel, Roy W Jones, Patrick G Kehoe, Hermine Lenoir, Lennart Minthon, Flavio M Nobili, Marcel Olde Rikkert, Anne-Sophie Rigaud, Philip Scheltens, Hilkka Soininen, Luiza Spiru, Magda TsolakiLars-Olof Wahlund, Bruno Vellas, Gordon Wilcock, Lyzel S Elias-Sonnenschein, Frans R J Verhey

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Abstract

We assessed the interaction between the APOE ε4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE ε4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.

Original language	English
Journal	Journal of Alzheimer's Disease
DOIs	https://doi.org/10.3233/JAD-122182
Publication status	Published - 2013

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Vermeiren, A. P. A., Bosma, H., Visser, P-J., Zeegers, M. P., Graff, C., Ewers, M., Frisoni, G. B., Frölich, L., Hampel, H., Jones, R. W., Kehoe, P. G., Lenoir, H., Minthon, L., Nobili, F. M., Olde Rikkert, M., Rigaud, A-S., Scheltens, P., Soininen, H., Spiru, L., ... Verhey, F. R. J. (2013). The Association Between APOE ε4 and Alzheimer-type Dementia among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study. Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-122182

@article{bfaa4d7b01724036b981107df2c74c9b,

title = "The Association Between APOE ε4 and Alzheimer-type Dementia among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study",

abstract = "We assessed the interaction between the APOE ε4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE ε4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.",

author = "Vermeiren, {Angelique P A} and Hans Bosma and Pieter-Jelle Visser and Zeegers, {Maurice P} and Caroline Graff and Michael Ewers and Frisoni, {Giovanni B} and Lutz Fr{\"o}lich and Harald Hampel and Jones, {Roy W} and Kehoe, {Patrick G} and Hermine Lenoir and Lennart Minthon and Nobili, {Flavio M} and {Olde Rikkert}, Marcel and Anne-Sophie Rigaud and Philip Scheltens and Hilkka Soininen and Luiza Spiru and Magda Tsolaki and Lars-Olof Wahlund and Bruno Vellas and Gordon Wilcock and Elias-Sonnenschein, {Lyzel S} and Verhey, {Frans R J}",

year = "2013",

doi = "10.3233/JAD-122182",

language = "English",

journal = "Journal of Alzheimer's Disease",

issn = "1875-8908",

publisher = "IOS Press",

}

Vermeiren, APA, Bosma, H, Visser, P-J, Zeegers, MP, Graff, C, Ewers, M, Frisoni, GB, Frölich, L, Hampel, H, Jones, RW, Kehoe, PG, Lenoir, H, Minthon, L, Nobili, FM, Olde Rikkert, M, Rigaud, A-S, Scheltens, P, Soininen, H, Spiru, L, Tsolaki, M, Wahlund, L-O, Vellas, B, Wilcock, G, Elias-Sonnenschein, LS & Verhey, FRJ 2013, 'The Association Between APOE ε4 and Alzheimer-type Dementia among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study', Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-122182

TY - JOUR

T1 - The Association Between APOE ε4 and Alzheimer-type Dementia among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study

AU - Vermeiren, Angelique P A

AU - Bosma, Hans

AU - Visser, Pieter-Jelle

AU - Zeegers, Maurice P

AU - Graff, Caroline

AU - Ewers, Michael

AU - Frisoni, Giovanni B

AU - Frölich, Lutz

AU - Hampel, Harald

AU - Jones, Roy W

AU - Kehoe, Patrick G

AU - Lenoir, Hermine

AU - Minthon, Lennart

AU - Nobili, Flavio M

AU - Olde Rikkert, Marcel

AU - Rigaud, Anne-Sophie

AU - Scheltens, Philip

AU - Soininen, Hilkka

AU - Spiru, Luiza

AU - Tsolaki, Magda

AU - Wahlund, Lars-Olof

AU - Vellas, Bruno

AU - Wilcock, Gordon

AU - Elias-Sonnenschein, Lyzel S

AU - Verhey, Frans R J

PY - 2013

Y1 - 2013

N2 - We assessed the interaction between the APOE ε4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE ε4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.

AB - We assessed the interaction between the APOE ε4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE ε4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.

U2 - 10.3233/JAD-122182

DO - 10.3233/JAD-122182

M3 - Article (Academic Journal)

C2 - 23380990

SN - 1875-8908

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

ER -

The Association Between APOE ε4 and Alzheimer-type Dementia among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study

Abstract

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