The association between birth weight and blood pressure in robust, amplifies with age, and may be underestimated

AA Davies, G Davey Smith, MT May, Y Ben-Shlomo

Research output: Contribution to journalArticle (Academic Journal)peer-review

86 Citations (Scopus)

Abstract

Data on the early life origins of adult hypertension have been widely reported: however, recent research shows that the strength of association between small size at birth and higher blood pressure weakens as study size increases. In this article, we retest the association between birth weight and systolic blood pressure in a large cohort, examine whether age interacts with birth weight to predict blood pressure, and explore reasons why birth weight-blood pressure associations tend to weaken with increasing study size. Measurements from 25874 employees of a large United Kingdom company (mean [SD] age: 38.0 [7.9] years), undertaking voluntary occupational health screening, were available. Using linear regression analysis, we observed that systolic blood pressure changed –0.8 (95% CI: –1.1 to –0.5) mmHg per 1-kg increase in birth weight (P
Translated title of the contributionThe association between birth weight and blood pressure in robust, amplifies with age, and may be underestimated
Original languageEnglish
Pages (from-to)431 - 436
Number of pages6
JournalHypertension
Volume48 (3)
DOIs
Publication statusPublished - Sep 2006

Bibliographical note

Publisher: American Heart Association

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