The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis

Hebe N Gouda, Gurdeep S Sagoo, Anne-Helen Harding, Jan Yates, Manjinder S Sandhu, Julian P T Higgins

Research output: Contribution to journalArticle (Academic Journal)peer-review

163 Citations (Scopus)

Abstract

The peroxisome proliferator-activated receptor-gamma gene (PPARG) has been implicated in the etiology of type 2 diabetes mellitus and has been investigated in numerous epidemiologic studies. In this Human Genome Epidemiology review, the authors assessed this relation in an updated meta-analysis of 60 association studies. Electronic literature searches were conducted on September 14, 2009. Population-based cohort, case-control, cross-sectional, or genome-wide association studies reporting associations between the PPARG Pro12Ala gene variant (rs1801282) and type 2 diabetes were included. An updated literature-based meta-analysis involving 32,849 type 2 diabetes cases and 47,456 controls in relation to the PPARG Pro12Ala variant was conducted. The combined overall odds ratio, calculated by per-allele genetic model random-effects meta-analysis for type 2 diabetes and the Pro12Ala polymorphism, was 0.86 (95% confidence interval: 0.81, 0.90). The analysis indicated a moderate level of heterogeneity attributable to genuine variation in gene effect size (I(2) = 37%). This may reflect the variation observed between ethnic populations and/or differences in body mass index. Work on PPARG Pro12Ala should now focus on the observed heterogeneity in the magnitude of the association between populations. Further investigations into gene-gene and gene-environment interactions may prove enlightening.

Original languageEnglish
Pages (from-to)645-55
Number of pages11
JournalAmerican Journal of Epidemiology
Volume171
Issue number6
DOIs
Publication statusPublished - 15 Mar 2010

Keywords

  • Diabetes Mellitus, Type 2
  • Gene Frequency
  • Genetic Heterogeneity
  • Genetic Predisposition to Disease
  • Humans
  • PPAR gamma
  • Polymorphism, Genetic
  • Regression Analysis

Fingerprint Dive into the research topics of 'The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis'. Together they form a unique fingerprint.

Cite this