The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood

Anna-Maija Tolppanen; Adrian E Sayers; William D Fraser; Glyn H Lewis; Stanley Zammit; Debbie A Lawlor

doi:10.1371/journal.pone.0040097

The association of 25-hydroxyvitamin D₃ and D₂ with behavioural problems in childhood

Anna-Maija Tolppanen, Adrian E Sayers, William D Fraser, Glyn H Lewis, Stanley Zammit, Debbie A Lawlor

Research output: Contribution to journal › Article (Academic Journal) › peer-review

33 Citations (Scopus)

263 Downloads (Pure)

Abstract

Background

Higher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D₃ (the active vitamin D₃ metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans.

Methods

We investigated the prospective association between the different forms of 25(OH)D - 25(OH)D₃ and 25(OH)D₂– and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D₃ and 25(OH)D₂ concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Difficulties Questionnaire (SDQ; emotional symptoms, conduct problems, hyperactivity-inattention problems, peer relationship problems and pro-social behaviour subscales and total difficulties score) at mean age 11.7. Sample sizes varied between 2413-2666 depending on the outcome.

Results

Higher 25(OH)D₃ concentrations were weakly associated with lower risk of prosocial problems (fully adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.74, 0.98)). Serum 25(OH)D₃ or 25(OH)D₂ concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D.

Conclusions

Our findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans.

Original language	English
Article number	e40097
Number of pages	8
Journal	PLoS ONE
Volume	7
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0040097
Publication status	Published - 10 Jul 2012

Keywords

25-Hydroxyvitamin D 2
Calcifediol
Child
Child Behavior Disorders
Confounding Factors (Epidemiology)
Humans
Surveys and Questionnaires

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0040097

journal.pone.0040097
This is the final published version of the article (version of record). It first appeared online via Public Library of Science at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040097
Final published version, 214 KBLicence: CC BY

Handle.net

Persistent link

Cite this

@article{0a1e5e97837c452c9879c046e5841d9a,

title = "The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood",

abstract = "Background Higher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D3 (the active vitamin D3 metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans. Methods We investigated the prospective association between the different forms of 25(OH)D - 25(OH)D3 and 25(OH)D2– and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D3 and 25(OH)D2 concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Difficulties Questionnaire (SDQ; emotional symptoms, conduct problems, hyperactivity-inattention problems, peer relationship problems and pro-social behaviour subscales and total difficulties score) at mean age 11.7. Sample sizes varied between 2413-2666 depending on the outcome. Results Higher 25(OH)D3 concentrations were weakly associated with lower risk of prosocial problems (fully adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.74, 0.98)). Serum 25(OH)D3 or 25(OH)D2 concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D. Conclusions Our findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans.",

keywords = "25-Hydroxyvitamin D 2, Calcifediol, Child, Child Behavior Disorders, Confounding Factors (Epidemiology), Humans, Surveys and Questionnaires",

author = "Anna-Maija Tolppanen and Sayers, {Adrian E} and Fraser, {William D} and Lewis, {Glyn H} and Stanley Zammit and Lawlor, {Debbie A}",

year = "2012",

month = jul,

day = "10",

doi = "10.1371/journal.pone.0040097",

language = "English",

volume = "7",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "7",

}

TY - JOUR

T1 - The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood

AU - Tolppanen, Anna-Maija

AU - Sayers, Adrian E

AU - Fraser, William D

AU - Lewis, Glyn H

AU - Zammit, Stanley

AU - Lawlor, Debbie A

PY - 2012/7/10

Y1 - 2012/7/10

N2 - Background Higher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D3 (the active vitamin D3 metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans. Methods We investigated the prospective association between the different forms of 25(OH)D - 25(OH)D3 and 25(OH)D2– and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D3 and 25(OH)D2 concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Difficulties Questionnaire (SDQ; emotional symptoms, conduct problems, hyperactivity-inattention problems, peer relationship problems and pro-social behaviour subscales and total difficulties score) at mean age 11.7. Sample sizes varied between 2413-2666 depending on the outcome. Results Higher 25(OH)D3 concentrations were weakly associated with lower risk of prosocial problems (fully adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.74, 0.98)). Serum 25(OH)D3 or 25(OH)D2 concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D. Conclusions Our findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans.

AB - Background Higher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D3 (the active vitamin D3 metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans. Methods We investigated the prospective association between the different forms of 25(OH)D - 25(OH)D3 and 25(OH)D2– and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D3 and 25(OH)D2 concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Difficulties Questionnaire (SDQ; emotional symptoms, conduct problems, hyperactivity-inattention problems, peer relationship problems and pro-social behaviour subscales and total difficulties score) at mean age 11.7. Sample sizes varied between 2413-2666 depending on the outcome. Results Higher 25(OH)D3 concentrations were weakly associated with lower risk of prosocial problems (fully adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.74, 0.98)). Serum 25(OH)D3 or 25(OH)D2 concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D. Conclusions Our findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans.

KW - 25-Hydroxyvitamin D 2

KW - Calcifediol

KW - Child

KW - Child Behavior Disorders

KW - Confounding Factors (Epidemiology)

KW - Humans

KW - Surveys and Questionnaires

UR - http://www.scopus.com/inward/record.url?scp=84863687145&partnerID=8YFLogxK

UR - http://orca.cf.ac.uk/79788/

U2 - 10.1371/journal.pone.0040097

DO - 10.1371/journal.pone.0040097

M3 - Article (Academic Journal)

C2 - 22808099

SN - 1932-6203

VL - 7

JO - PLoS ONE

JF - PLoS ONE

IS - 7

M1 - e40097

ER -

The association of 25-hydroxyvitamin D₃ and D₂ with behavioural problems in childhood

Abstract

Keywords

UN SDGs

Access to Document

Handle.net

Other files and links

Fingerprint

THE PUBLIC HEALTH IMPORTANCE OF VITAMIN D: DETERMINING CAUSAL EFFECTS OF INTRAUTERINE AND LIFETIME EXPOSURE TO VITAMIN D

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

Cite this

The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood

Abstract

Keywords

UN SDGs

Access to Document

Handle.net

Other files and links

Fingerprint

Projects

THE PUBLIC HEALTH IMPORTANCE OF VITAMIN D: DETERMINING CAUSAL EFFECTS OF INTRAUTERINE AND LIFETIME EXPOSURE TO VITAMIN D

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

Cite this

The association of 25-hydroxyvitamin D₃ and D₂ with behavioural problems in childhood