The Association of Early Life Supplemental Nutrition With Lean Body Mass and Grip Strength in Adulthood: Evidence From APCAPS

Bharati Kulkarni, Hannah Kuper, K V Radhakrishna, Andrew P Hills, Nuala M Byrne, Amy Taylor, Ruth Sullivan, Liza Bowen, Jonathan C Wells, Yoav Ben-Shlomo, George Davey Smith, Shah Ebrahim, Sanjay Kinra

Research output: Contribution to journalArticle (Academic Journal)peer-review

13 Citations (Scopus)

Abstract

In the present study, we examined the associations of early nutrition with adult lean body mass (LBM) and muscle strength in a birth cohort that was established to assess the long-term impact of a nutrition program. Participants (n = 1,446, 32% female) were born near Hyderabad, India, in 29 villages from 1987 to 1990, during which time only intervention villages (n = 15) had a government program that offered balanced protein-calorie supplementation to pregnant women and children. Participants' LBM and appendicular skeletal muscle mass were measured using dual energy x-ray absorptiometry; grip strength and information on lifestyle indicators, including diet and physical activity level, were also obtained. Ages (mean = 20.3 years) and body mass indexes (weight (kg)/height (m)(2); mean = 19.5) of participants in 2 groups were similar. Current dietary energy intake was higher in the intervention group. Unadjusted LBM and grip strength were similar in 2 groups. After adjustment for potential confounders, the intervention group had lower LBM (β = -0.75; P = 0.03), appendicular skeletal muscle mass, and grip strength than did controls, but these differences were small in magnitude (
Original languageEnglish
Pages (from-to)700-709
Number of pages9
JournalAmerican Journal of Epidemiology
DOIs
Publication statusPublished - 19 Feb 2014

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

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