The Association of Serum Ionized Calcium and Vitamin D With Adult Cognitive Performance

AM Tolppanen, DM Williams, D Lawlor

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)

Abstract

BACKGROUND: High serum calcium levels have been associated with cognitive decline in older adults. These associations have not been studied in younger adults. The possible association of vitamin D with cognitive function, independent of calcium, is unknown. METHODS: A cross-sectional study of associations of serum ionized calcium and 25-hydroxyvitamin D levels with cognitive function in younger adults (20-59 years) and older adults (60-90 years) was conducted using data from the US third National Health and Nutrition Examination Survey (NHANES III). RESULTS: Neither serum ionized calcium nor 25-hydroxyvitamin D was associated with cognitive function in either age group. For example, the confounder-adjusted mean difference in reaction time in young adults was 0.00 (95% confidence intervala= -0.07 to 0.06) per 1 SD calcium. CONCLUSION: Our results do not support an important role for calcium or vitamin D in cognitive performance in adults.
Translated title of the contributionThe Association of Serum Ionized Calcium and Vitamin D With Adult Cognitive Performance
Original languageEnglish
Pages (from-to)113 - 117
Number of pages5
JournalEpidemiology
Volume22
DOIs
Publication statusPublished - Jan 2010

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