The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies

Eleanor L. Watts*, Aurora Perez-Cornago, Paul N. Appleby, Demetrius Albanes, Eva Ardanaz, Amanda Black, H. Bas Bueno-de-Mesquita, June M. Chan, Chu Chen, S. A. Paul Chubb, Michael B. Cook, Mélanie Deschasaux, Jenny L. Donovan, Dallas R. English, Leon Flicker, Neal D. Freedman, Pilar Galan, Graham G. Giles, Edward L. Giovannucci, Marc J. GunterLaurel A. Habel, Christel Häggström, Christopher Haiman, Freddie C. Hamdy, Serge Hercberg, Jeff M. Holly, Jiaqi Huang, Wen Yi Huang, Mattias Johansson, Rudolf Kaaks, Tatsuhiko Kubo, J. Athene Lane, Tracy M. Layne, Loic Le Marchand, Richard M. Martin, E. Jeffrey Metter, Kazuya Mikami, Roger L. Milne, Howard A. Morris, Lorelei A. Mucci, David E. Neal, Marian L. Neuhouser, Steven E. Oliver, Kim Overvad, Kotaro Ozasa, Valeria Pala, Claire H. Pernar, Michael Pollak, Mari Anne Rowlands, Catherine A. Schaefer, Jeannette M. Schenk, Pär Stattin, Akiko Tamakoshi, Elin Thysell, Mathilde Touvier, Antonia Trichopoulou, Konstantinos K. Tsilidis, Stephen K. Van Den Eeden, Stephanie J. Weinstein, Lynne Wilkens, Bu B. Yeap, Timothy J. Key, Naomi E. Allen, Ruth C. Travis

*Corresponding author for this work

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Abstract

Insulin‐like growth factors (IGFs) and insulin‐like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross‐sectional associations of these exposures with circulating concentrations of IGFs (IGF‐I and IGF‐II) and IGFBPs (IGFBP‐1, IGFBP‐2 and IGFBP‐3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22–89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP‐1 and IGFBP‐2 and lower concentrations of IGF‐I, IGF‐II and IGFBP‐3. Higher body mass index was associated with lower concentrations of IGFBP‐1 and IGFBP‐2. Taller height was associated with higher concentrations of IGF‐I and IGFBP‐3 and lower concentrations of IGFBP‐1. Smokers had higher concentrations of IGFBP‐1 and IGFBP‐2 and lower concentrations of IGFBP‐3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF‐II and lower concentrations of IGF‐I and IGFBP‐2. African Americans had lower concentrations of IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 and Hispanics had lower IGF‐I, IGF‐II and IGFBP‐3 than non‐Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.
Original languageEnglish
Pages (from-to)3244-3256
Number of pages14
JournalInternational Journal of Cancer
Volume145
Issue number12
Early online date4 Apr 2019
DOIs
Publication statusPublished - 15 Dec 2019

Structured keywords

  • ICEP
  • Centre for Surgical Research

Keywords

  • correlates
  • IGFBPs
  • IGFs
  • pooled analysis

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    NIHR BRC Nutrition

    Ness, A. R.

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    Cite this

    Watts, E. L., Perez-Cornago, A., Appleby, P. N., Albanes, D., Ardanaz, E., Black, A., Bueno-de-Mesquita, H. B., Chan, J. M., Chen, C., Chubb, S. A. P., Cook, M. B., Deschasaux, M., Donovan, J. L., English, D. R., Flicker, L., Freedman, N. D., Galan, P., Giles, G. G., Giovannucci, E. L., ... Travis, R. C. (2019). The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies. International Journal of Cancer, 145(12), 3244-3256. https://doi.org/10.1002/ijc.32276