The Associations of high levels of C-reactive proteim with depression and myocardial infarction in 9258 women and men from the HUNT population study

O Bjerkeset, U Romild, G Davey Smith, K Hveem

Research output: Contribution to journalArticle (Academic Journal)peer-review

27 Citations (Scopus)

Abstract

BACKGROUND: Elevated levels of circulating C-reactive protein (CRP) have been associated with coronary heart disease and, in some studies, depression. Most studies have been of populations selected by age and/or gender. We investigate these associations with depression, myocardial infarction (MI), or both, in a large general population sample. METHOD: A cross-sectional population study of 9258 women and men aged ≥ 20 years. The study included clinical examination, self-report of MI and depression and factors known to confound their associations. The Hospital Anxiety and Depression Scale was used to assess severity of depressive symptoms. Elevated high sensitive-CRP was defined as values >2.2 mg/l. RESULTS: The association of elevated CRP with depression was attenuated towards the null [from odds ratio (OR) 1.28, p=0.001 to OR 1.08, p=0.388] following extensive adjustment, while associations with MI (adjusted OR 1.42, p=0.032) and co-morbid MI and depression (adjusted OR 2.66, p=0.003) persisted. Confounders associated with elevated CRP levels were smoking (OR 1.66; p
Translated title of the contributionThe Associations of high levels of C-reactive proteim with depression and myocardial infarction in 9258 women and men from the HUNT population study
Original languageEnglish
Pages (from-to)345 - 352
Number of pages7
JournalPsychological Medicine
Volume41
DOIs
Publication statusPublished - Feb 2011

Fingerprint Dive into the research topics of 'The Associations of high levels of C-reactive proteim with depression and myocardial infarction in 9258 women and men from the HUNT population study'. Together they form a unique fingerprint.

Cite this