The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design

Rajiv Chowdhury, Dewan S Alam, Ismail Ibrahim Fakir, Sheikh Daud Adnan, Aliya Naheed, Ishrat Tasmin, Md Mostafa Monower, Farzana Hossain, Fatema Mahjabin Hossain, Md Mostafizur Rahman, Sadia Afrin, Anjan Kumar Roy, Minara Akter, Sima Akter Sume, Ajoy Kumer Biswas, Lisa Pennells, Praveen Surendran, Robin D Young, Sarah A Spackman, Khaled HasanEric Harshfield, Nasir Sheikh, Richard Houghton, Danish Saleheen, Joanna M M Howson, Adam S Butterworth, Rubhana Raqib, Abdulla Al Shafi Majumder, John Danesh, Emanuele Di Angelantonio, Cardiology Research Group, Narinder Bansal

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)

Abstract

During recent decades, Bangladesh has experienced a rapid epidemiological transition from communicable to non-communicable diseases. Coronary heart disease (CHD), with myocardial infarction (MI) as its main manifestation, is a major cause of death in the country. However, there is limited reliable evidence about its determinants in this population. The Bangladesh Risk of Acute Vascular Events (BRAVE) study is an epidemiological bioresource established to examine environmental, genetic, lifestyle and biochemical determinants of CHD among the Bangladeshi population. By early 2015, the ongoing BRAVE study had recruited over 5000 confirmed first-ever MI cases, and over 5000 controls "frequency-matched" by age and sex. For each participant, information has been recorded on demographic factors, lifestyle, socioeconomic, clinical, and anthropometric characteristics. A 12-lead electrocardiogram has been recorded. Biological samples have been collected and stored, including extracted DNA, plasma, serum and whole blood. Additionally, for the 3000 cases and 3000 controls initially recruited, genotyping has been done using the CardioMetabochip+ and the Exome+ arrays. The mean age (standard deviation) of MI cases is 53 (10) years, with 88 % of cases being male and 46 % aged 50 years or younger. The median interval between reported onset of symptoms and hospital admission is 5 h. Initial analyses indicate that Bangladeshis are genetically distinct from major non-South Asian ethnicities, as well as distinct from other South Asian ethnicities. The BRAVE study is well-placed to serve as a powerful resource to investigate current and future hypotheses relating to environmental, biochemical and genetic causes of CHD in an important but under-studied South Asian population.

Original languageEnglish
Pages (from-to)577-87
Number of pages11
JournalEuropean Journal of Epidemiology
Volume30
Issue number7
DOIs
Publication statusPublished - Jul 2015

Keywords

  • Adult
  • Aged
  • Asian Continental Ancestry Group
  • Bangladesh
  • Case-Control Studies
  • Coronary Artery Disease
  • Coronary Disease
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Risk
  • Risk Factors

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