The bone marrow pericyte: An orchestrator of vascular niche

Giuseppe Mangialardi*, Andrea Cordaro, Paolo Madeddu

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

15 Citations (Scopus)
247 Downloads (Pure)

Abstract

The concept of pericyte has been changing over years. This cell type was believed to possess only a function of trophic support to endothelial cells and to maintain vasculature stabilization. In the last years, the discovery of multipotent ability of perivascular populations led to the concept of vessel/wall niche. Likewise, several perivascular populations have been identified in animal and human bone marrow. In this review, we provide an overview on bone marrow perivascular population, their cross-talk with other niche components, relationship with bone marrow stromal stem cells, and similarities and differences with the perivascular population of the vessel/wall niche. Finally, we focus on the regenerative potential of these cells and the forthcoming challenges related to their use as cell therapy products.

Original languageEnglish
Pages (from-to)883-895
Number of pages13
JournalRegenerative Medicine
Volume11
Issue number8
Early online date25 Nov 2016
DOIs
Publication statusE-pub ahead of print - 25 Nov 2016

Keywords

  • bone marrow
  • CD146
  • endosteal niche
  • Nestin
  • perivascular cell
  • vascular niche

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