The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease

Patrick G. Kehoe, Hywel Williams, Peter Holmans, Gordon Wilcock, Nigel J. Cairns, Jim Neal, Michael J. Owen*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

29 Citations (Scopus)


Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the ε4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p = 0.75) or alleles (p = 0.70) between patients and controls. Moreover, despite a significant excess of ApoE ε4 in patients versus controls (p < 0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (χ2 = 1.49, df = 4, p = 0.83).

Original languageEnglish
Pages (from-to)1034-1035
Number of pages2
JournalJournal of Medical Genetics
Issue number12
Publication statusPublished - 1998


  • Alzheimer's disease
  • Butyrylcholinesterase K variant
  • Genetics


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