The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease

Patrick G. Kehoe; Hywel Williams; Peter Holmans; Gordon Wilcock; Nigel J. Cairns; Jim Neal; Michael J. Owen

The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease

Patrick G. Kehoe, Hywel Williams, Peter Holmans, Gordon Wilcock, Nigel J. Cairns, Jim Neal, Michael J. Owen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

29 Citations (Scopus)

Abstract

Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the ε4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p = 0.75) or alleles (p = 0.70) between patients and controls. Moreover, despite a significant excess of ApoE ε4 in patients versus controls (p < 0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (χ² = 1.49, df = 4, p = 0.83).

Original language	English
Pages (from-to)	1034-1035
Number of pages	2
Journal	Journal of Medical Genetics
Volume	35
Issue number	12
Publication status	Published - 1998

Research Groups and Themes

Cerebrovascular and Dementia Research Group

Keywords

Alzheimer's disease
Butyrylcholinesterase K variant
Genetics

Handle.net

Persistent link

Cite this

@article{3d0ec5fdc6a24628be27b1962459787c,

title = "The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease",

abstract = "Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the ε4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p = 0.75) or alleles (p = 0.70) between patients and controls. Moreover, despite a significant excess of ApoE ε4 in patients versus controls (p < 0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (χ2 = 1.49, df = 4, p = 0.83).",

keywords = "Alzheimer's disease, Butyrylcholinesterase K variant, Genetics",

author = "Kehoe, {Patrick G.} and Hywel Williams and Peter Holmans and Gordon Wilcock and Cairns, {Nigel J.} and Jim Neal and Owen, {Michael J.}",

year = "1998",

language = "English",

volume = "35",

pages = "1034--1035",

journal = "Journal of Medical Genetics",

issn = "0022-2593",

publisher = "BMJ Publishing Group",

number = "12",

}

TY - JOUR

T1 - The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease

AU - Kehoe, Patrick G.

AU - Williams, Hywel

AU - Holmans, Peter

AU - Wilcock, Gordon

AU - Cairns, Nigel J.

AU - Neal, Jim

AU - Owen, Michael J.

PY - 1998

Y1 - 1998

N2 - Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the ε4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p = 0.75) or alleles (p = 0.70) between patients and controls. Moreover, despite a significant excess of ApoE ε4 in patients versus controls (p < 0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (χ2 = 1.49, df = 4, p = 0.83).

AB - Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the ε4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p = 0.75) or alleles (p = 0.70) between patients and controls. Moreover, despite a significant excess of ApoE ε4 in patients versus controls (p < 0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (χ2 = 1.49, df = 4, p = 0.83).

KW - Alzheimer's disease

KW - Butyrylcholinesterase K variant

KW - Genetics

UR - http://www.scopus.com/inward/record.url?scp=0031757256&partnerID=8YFLogxK

M3 - Article (Academic Journal)

C2 - 9863603

AN - SCOPUS:0031757256

SN - 0022-2593

VL - 35

SP - 1034

EP - 1035

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

IS - 12

ER -

The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease

Abstract

Research Groups and Themes

Keywords

Handle.net

Other files and links

Fingerprint

Cite this