The carotid baroreflex is reset following prolonged exercise in humans

Emma C J Hart, P Rasmussen, N H Secher, Kimberley P George, N T Cable, S Volianitis, R Shave

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Abstract

AIM: Alterations in the carotid baroreflex (CBR) control of arterial pressure may explain the reduction in arterial pressure and left ventricular (LV) function after prolonged exercise. We examined the CBR control of heart rate (HR) and mean arterial pressure (MAP), in addition to changes in LV function, pre- to post-exercise.

METHODS: Seven males (age, mean ± SEM; 29 ± 4 years) completed 4 h of ergometer rowing at a workload of 10-15% below the lactate threshold. The CBR control of HR and MAP was assessed via the rapid neck-suction/pressure protocol. LV systolic function was measured by echocardiography, where ejection fraction (EF), the ratio of systolic blood pressure to end systolic volume (SBP/ESV) and stroke volume (SV) were estimated.

RESULTS: Following exercise MAP was reduced (12 ± 3%) and HR was elevated (35 ± 5%; P < 0.05). Furthermore, CBR control of MAP was relocated to the left on the stimulus-response curve (P < 0.05) demonstrating that the CBR operated around a lower arterial pressure. Concomitantly, LV systolic function was reduced, indicated by a decrease in EF (22 ± 2%), SBP/ESV (32 ± 14%) and SV (25 ± 5%, P < 0.05). The reduced EF and SBP/ESV were associated with the decreased MAP operating point (r² = 0.71 and r² = 0.47, respectively, P < 0.05).

CONCLUSION: The CBR is reset after prolonged exercise to a lower prevailing arterial pressure. This resetting of the CBR may contribute to the reduction arterial pressure and LV function after exercise.

Translated title of the contributionThe carotid baroreflex is reset following prolonged exercise in humans
Original languageEnglish
Pages (from-to)291-299
Number of pages9
JournalActa Physiologica
Volume200
Issue number4
Early online date8 Nov 2010
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Adult
  • Baroreflex
  • Blood Pressure
  • Carotid Arteries
  • Echocardiography
  • Exercise
  • Heart Rate
  • Hemodynamics
  • Humans
  • Male
  • Stroke Volume
  • Ventricular Function, Left

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  • Cite this

    Hart, E. C. J., Rasmussen, P., Secher, N. H., George, K. P., Cable, N. T., Volianitis, S., & Shave, R. (2010). The carotid baroreflex is reset following prolonged exercise in humans. Acta Physiologica, 200(4), 291-299. https://doi.org/10.1111/j.1748-1716.2010.02160.x