The catalytic ortho-arylation of tyrosine

Robin B. Bedford, Mairi F. Haddow, Ruth L. Webster, Charlotte J. Mitchell

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Abstract

The rhodium-catalysed direct ortho-arylation of protected racemic 2-tert-butyl tyrosine has been developed. The subsequent removal of the tert-butyl group yields the 2-arylated tyrosine which can undergo further rhodium-based arylation at the 6-position. In one instance a product formed by further arylation of the diarylated species was isolated.

Original languageEnglish
Pages (from-to)3119-3127
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume7
Issue number15
DOIs
Publication statusPublished - 2009

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