The chemical and ultra-structural analysis of thin plastic films used for surgical attenuation of portosystemic shunts in dogs and cats

Elinor J. Field, David J. Scurr, Matthew J. Piggott, Thomas S. Anderson, Guillaume P. Chanoit*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
12 Downloads (Pure)

Abstract

The objective of the study was to (1) characterize and compare the chemical composition at the surface, subsurface and in the bulk of thin plastic films used for portosystemic shunt attenuation in their native state and after plasma exposure. (2) Assess the presence, concentration and location of irritant compounds (e.g dicetyl phosphate) within the films. Attenuated Total Reflectance Infrared Spectroscopy (ATR-IR), X-ray Photoelectron Spectroscopy (XPS) and dynamic Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) were used to analyze thirteen thin plastic films. Sample thickness was visualized and measured using Scanning Electron Microscopy (SEM). Sample thicknesses were compared using a one-way ANOVA. XPS reported low phosphorous concentrations (surrogate marker of dicetyl phosphate) between 0.01-0.19% wt at the sample surfaces (top 10nm). There were significant differences between film thicknesses (P<0.001) observed by SEM. The ATR-IR and ToF-SIMS identified four distinct surface and bulk chemical profiles: 1) Cellophane, 2) Polypropylene, 3) Modified Cellophane, and 4) Unique. Following plasma immersion for 6 weeks, samples showed little change in film thickness or chemical composition. This study confirmed that films used to attenuate portosystemic shunts were commonly not pure cellophane, with significant variations in surface and bulk chemistry. Suspected irritant compounds were not readily identifiable in significant proportions. Pronounced variability existed in both the thickness and chemical composition of these films (surface vs. bulk). The present findings lead to a legitimate question about the reproducibility of shunt occlusion when using thin plastic films from different origins.
Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalResearch in Veterinary Science
Volume126
Early online date23 Aug 2019
DOIs
Publication statusPublished - 1 Oct 2019

Keywords

  • portosystemic shunt
  • cellophane band
  • thin plastic film
  • chemistry
  • spectroscopy

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