The concept of sporadic cerebral small vessel disease: A road map on key definitions and current concepts

Andreas Charidimou, Leonardo Pantoni, Seth Love

Research output: Contribution to journalArticle (Academic Journal)

53 Citations (Scopus)
420 Downloads (Pure)

Abstract

Sporadic cerebral small vessel disease is considered to be among the most common known neuropathological processes and has an important role in stroke, cognitive impairment, and functional loss in elderly persons. The term is now commonly used to describe a range of neuroimaging, neuropathological, and associated clinical features, the pathogenesis of which is largely unclear but that are thought to arise from disease affecting the perforating cerebral arterioles, capillaries, and venules. Modern neuroimaging has revolutionized our understanding of the consequences of small vessels disease on the brain parenchyma, even though small arteries, arterioles, capillaries, and venules are difficult to be directly visualized with current techniques used in clinical practice. In this short review, we focus on histopathological and neuroimaging perspectives, basic definitions, and recent advances in the field.

Original languageEnglish
Pages (from-to)6-18
Number of pages13
JournalInternational Journal of Stroke
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Cerebral microbleeds
  • cerebral small vessel disease
  • cerebral amyloid angiopathy
  • intracerebral hemorrhage
  • antithrombotics
  • leukoaraiosis

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