The CRP Genotype, Serum Levels and Lung Function in men: The Caerphilly Prospective Study

CE Bolton, W Schumacher, JR Cockroft, NJ Timpson, G Davey Smith, J Gallacher, A Rumley, GDO Lowe, S Ebrahim, D Shale, Y Ben-Shlomo

Research output: Contribution to journalArticle (Academic Journal)peer-review

23 Citations (Scopus)

Abstract

Systemic CRP (C-reactive protein) has been associated with impaired lung function. A causal relationship would increase the value of CRP as both a diagnostic and therapeutic tool. We assessed the association between lung function parameters, circulating CRP and CRP polymorphisms using Mendelian randomization in efforts to attribute causality to known associations. Spirometric parameters of FEV1 (forced expiratory volume in 1 s) and FVC (forced vital capacity) were determined in 2173 men participating in the Caerphilly Prospective Study. Lung function measures on 1021 participants were available at follow-up (mean, 16.8 years later). Serum CRP levels were measured at baseline, and three CRP polymorphisms were analysed. Haplotype analysis was performed. Serum CRP levels at baseline were inversely associated with contemporaneous FEV1 and FVC as well as at follow-up (P
Translated title of the contributionThe CRP Genotype, Serum Levels and Lung Function in men: The Caerphilly Prospective Study
Original languageEnglish
Pages (from-to)347 - 355
Number of pages8
JournalClinical Science
Volume120
DOIs
Publication statusPublished - Apr 2011

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